U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    mlh3 mutL homolog 3 (E. coli) [ Danio rerio (zebrafish) ]

    Gene ID: 568323, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mlh3provided by ZNC
    Official Full Name
    mutL homolog 3 (E. coli)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-45
    See related
    Ensembl:ENSDARG00000056334 AllianceGenome:ZFIN:ZDB-GENE-060810-45
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7152582; si:dkey-31b16.12
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (24589167..24598927)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (24662584..24672384)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-31b16.11 Neighboring gene transmembrane protein 240a Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene NCK-associated protein 5-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. Xia H, et al. Genetics, 2018 Feb. PMID 29196300, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA mismatch repair protein Mlh3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      24589167..24598927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469962.1 → XP_021325637.1  DNA mismatch repair protein Mlh3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P5H1
      Related
      ENSDARP00000120332.1, ENSDART00000143694.2
      Conserved Domains (2) summary
      smart00853
      Location:889 → 1070
      MutL_C; MutL C terminal dimerisation domain
      cl28386
      Location:2 → 462
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]

    2. XM_021469963.1 → XP_021325638.1  DNA mismatch repair protein Mlh3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFG3
      Conserved Domains (2) summary
      smart00853
      Location:788 → 969
      MutL_C; MutL C terminal dimerisation domain
      cl28386
      Location:2 → 462
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395151.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      209175..219261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162210.4 → XP_005162267.2  DNA mismatch repair protein Mlh3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B931
      Conserved Domains (3) summary
      smart00853
      Location:889 → 1070
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
      cl28386
      Location:2 → 462
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]

    2. XM_691647.7 → XP_696739.5  DNA mismatch repair protein Mlh3 isoform X2

      UniProtKB/TrEMBL
      A0A8N7T846
      Conserved Domains (3) summary
      smart00853
      Location:788 → 969
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
      cl28386
      Location:1 → 325
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous