TERT telomerase reverse transcriptase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TERTprovided by VGNC
Official Full Name: telomerase reverse transcriptaseprovided by VGNC
Primary source: VGNC:VGNC:47255
See related: Ensembl:ENSCAFG00845025817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	34	NC_051838.1 (11189290..11208463)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	34	NC_006616.4 (15798490..15817661)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	34	NC_049255.1 (11430438..11449614)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	34	NC_049294.1 (11240107..11259262)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	34	NC_049775.1 (11219414..11238599)

Chromosome 34 - NC_051838.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In deriving canine induced pluripotent stem cells (iPSC's), the reactivation of TERT (telomerase reverse transcriptase) in all four dog iPS cell lines supports epigenetic and nuclear reprogramming to pluripotency from adult canine fibroblasts.
Title: Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts.
This study evaluated the relationship between polymorphisms of Telomerase Reverse Transcriptase and the longevity and cancer susceptibility of 4 dog breeds.
Title: Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility.
This study reports that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines.
Title: The human and canine TERT promoters function equivalently in human and canine cells.
TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC.
Title: ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells.
DNA sequencing revealed two insertions (175 and 28 bp long) and two deletions (17 and 32 bp long), which were encountered in different combinations and gave rise to five different transcripts.
Title: Canis familiaris telomerase reverse transcriptase undergoes alternative splicing.
These findings suggest that telomerase may be a valuable target for canine osteosarcoma (OSA) therapy, and that telomerase status does not appear to be a prognostic factor in canine OSA.
Title: Impact of telomerase status on canine osteosarcoma patients.
Localization of catalytic subunit of telomerase reverse transcriptase in normal lens epithelial cells(LEC)corresponded with LEC's regional functions. (Catalytic subunit of telomerase reverse transcriptase)
Title: Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells.
A higher expression of TERT was noted in canine and feline meningionas.
Title: Immunohistochemical expression of h-telomerase reverse transcriptase in canine and feline meningiomas.
Dog TERT shows the highest level of sequence similarity to the human TERT protein, supporting the dog as a model system for telomerase-based studies.
Title: Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of telomerase catalytic core complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: telomerase reverse transcriptase

Names: telomerase catalytic subunit; telomerase reverse transcriptase subunit

NP_001026800.2

EC 2.7.7.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031630.2 → NP_001026800.2 telomerase reverse transcriptase

Status: VALIDATED

Source sequence(s)

AF380351, JAAUVH010000363

UniProtKB/Swiss-Prot

Q6A548

Related

ENSCAFP00845035755.1, ENSCAFT00845045580.1

Conserved Domains (2) summary

cd01648
Location:815 → 926

TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

pfam12009
Location:449 → 575

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain