EMB2757 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: EMB2757
Gene description: Transducin/WD40 repeat-like superfamily protein
Primary source: Araport:AT4G29860
Locus tag: AT4G29860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ALT2; ALUMINUM TOLERANT 2; AtDSE1; DECREASED SIZE EXCLUSION LIMIT 1; DSE1; EMBRYO DEFECTIVE 2757; F27B13.100; F27B13_100; TAN; TANMEI
Summary: Encodes a WD repeat protein with seven WD repeat motifs, predicted to function in protein-protein interaction. Mutations caused defects in both embryo and seedling development.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

ALT2 (AT4G29860) function together with SOG1 and ATR to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.
Title: Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
DSE1 is important for regulating plasmodesmata transport between plant cells. [DSE1]
Title: Plasmodesmata formation and cell-to-cell transport are reduced in decreased size exclusion limit 1 during embryogenesis in Arabidopsis.
TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.
Title: The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition.
TAN interacts with other proteins to control many aspects of embryo development [TAN]
Title: TANMEI/EMB2757 encodes a WD repeat protein required for embryo development in Arabidopsis.

Submit: New GeneRIF Correction

NM_119132.3

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA integrity checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acquisition of desiccation tolerance in seed	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	NAS Non-traceable Author Statement more info
involved_in plant ovule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmodesma organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmodesmata-mediated intercellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to aluminum ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cisplatin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_194715.2

EMBRYO DEFECTIVE 2757 (EMB2757); FUNCTIONS IN: nucleotide binding; INVOLVED IN: acquisition of desiccation tolerance, embryo development, embryo development ending in seed dormancy; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: stem, rosette leaf, fruit, root, cultured cell; EXPRESSED DURING: F mature embryo stage, D bilateral stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1); Has 24053 Blast hits to 12842 proteins in 620 species: Archae - 42; Bacteria - 6408; Metazoa - 6694; Fungi - 5230; Plants - 2600; Viruses - 0; Other Eukaryotes - 3079 (source: NCBI BLink).

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