PHLDA2 pleckstrin homology like domain family A member 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PHLDA2provided by VGNC
Official Full Name: pleckstrin homology like domain family A member 2provided by VGNC
Primary source: VGNC:VGNC:32836
See related: BGD:BT11904; Ensembl:ENSBTAG00000031194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (48689532..48690588)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genes critical for placental development were altered in nuclear transfer placentas, including an imprinted gene. Allele-specific changes in the permissive histone mark in the PHLDA2 promoter indicate misregulation of imprinting in clones.
Title: Nuclear transfer alters placental gene expression and associated histone modifications of the placental-specific imprinted gene pleckstrin homology-like domain, family A, member 2 (PHLDA2) in cattle.
imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues, were assessed in cattle.
Title: Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle.
proper expression levels of the imprinted genes CDKN1C and PHLDA2 are critical for embryo development
Title: Knockdown of CDKN1C (p57(kip2)) and PHLDA2 results in developmental changes in bovine pre-implantation embryos.
Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.
Title: PHLDA2 is an imprinted gene in cattle.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in placenta development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pleckstrin homology-like domain family A member 2

Names: imprinted in placenta and liver protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.