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    CRCP CGRP receptor component [ Homo sapiens (human) ]

    Gene ID: 27297, updated on 13-Apr-2024

    Summary

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    Official Symbol
    CRCPprovided by HGNC
    Official Full Name
    CGRP receptor componentprovided by HGNC
    Primary source
    HGNC:HGNC:17888
    See related
    Ensembl:ENSG00000241258 MIM:606121; AllianceGenome:HGNC:17888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP
    Summary
    This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q11.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66114818..66154568)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67336904..67376648)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65579805..65619555)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26080 Neighboring gene golgin A7 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65551291-65551918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65565192-65565753 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65578710-65578900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65580214-65580742 Neighboring gene argininosuccinate lyase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:65612993-65614192 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65642926-65643089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18205 Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene MPRA-validated peak6545 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:65779787-65780442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65814565-65815064 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65827447-65827611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853152-65853652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853653-65854153 Neighboring gene long intergenic non-protein coding RNA 174 Neighboring gene uncharacterized LOC124901822

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. Miranda LP, et al. J Med Chem, 2008 Dec 25. PMID 19053766
    2. Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR. Conner M, et al. Biochemistry, 2008 Aug 12. PMID 18636754
    3. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Goharkhay N, et al. Am J Perinatol, 2007 Sep. PMID 17853344
    4. Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. Zuccarello D, et al. J Endocrinol Invest, 2004 Sep. PMID 15636430
    5. Anti-CGRP and anti-CGRP receptor monoclonal antibodies as antimigraine agents. Potential differences in safety profile postulated on a pathophysiological basis. Tringali G, et al. Peptides, 2019 Jun. PMID 31018157

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both anti-CGRP and anti-CGRP receptor monoclonal antibodies (mABs) completed clinical development, and the first representatives of these 2 classes are available on the market. MABs are approved for prevention of migraine attacks in chronic or episodic migraine, involving long-term treatments.
      Title: Anti-CGRP and anti-CGRP receptor monoclonal antibodies as antimigraine agents. Potential differences in safety profile postulated on a pathophysiological basis.
    2. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine
      Title: Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.
    3. CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways.
      Title: Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
    4. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed.
      Title: Calcitonin gene related family peptides: importance in normal placental and fetal development.
    5. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
      Title: Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex.
      Title: Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor.
    8. Data describe the role of residues 23-60 of the calcitonin receptor-like receptor in binding with interaction sites within the N-terminus of the calcitonin gene-related peptide receptor.
      Title: Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor.
    9. analysis of the effects of antagonists to the CGRP receptor
      Title: Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
    10. A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane.
      Title: Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111194

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcitonin gene-related peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC9
    Names
    CGRP-receptor component protein
    RNA polymerase III subunit C9
    calcitonin gene-related peptide-receptor component protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040647.2 → NP_001035737.1  DNA-directed RNA polymerase III subunit RPC9 isoform b

      See identical proteins and their annotated locations for NP_001035737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC068533, BC040107, BC052570, BI600330
      Consensus CDS
      CCDS47599.1
      UniProtKB/Swiss-Prot
      O75575
      Related
      ENSP00000340044.5, ENST00000338592.5
      Conserved Domains (1) summary
      cl00638
      Location:14 → 94
      RNA_pol_Rpb4; RNA polymerase Rpb4

    2. NM_001040648.2 → NP_001035738.1  DNA-directed RNA polymerase III subunit RPC9 isoform c

      See identical proteins and their annotated locations for NP_001035738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons but maintains the reading frame, compared to variant 1, resulting in a much shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AC068533, BC052570, DB472426
      Consensus CDS
      CCDS47600.1
      UniProtKB/Swiss-Prot
      O75575
      Related
      ENSP00000381674.2, ENST00000398684.6
      Conserved Domains (1) summary
      cl00638
      Location:4 → 50
      RNA_pol_Rpb4; RNA polymerase Rpb4

    3. NM_001142414.1 → NP_001135886.1  DNA-directed RNA polymerase III subunit RPC9 isoform d

      See identical proteins and their annotated locations for NP_001135886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' region, which results in an upstream AUG start codon, and also lacks an exon in the middle region, as compared to variant 1. The reading frame is not affected, and the resulting isoform (d) is shorter and has a distinct N-terminus, as compared to isoform a.
      Source sequence(s)
      AC068533, AK303737, DA821665
      Consensus CDS
      CCDS55116.1
      UniProtKB/Swiss-Prot
      O75575
      Related
      ENSP00000388653.2, ENST00000431089.6
      Conserved Domains (1) summary
      cl00638
      Location:40 → 120
      RNA_pol_Rpb4; RNA polymerase Rpb4

    4. NM_014478.5 → NP_055293.1  DNA-directed RNA polymerase III subunit RPC9 isoform a

      See identical proteins and their annotated locations for NP_055293.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC068533, BC052570, BC105808, BI600330, U51134
      Consensus CDS
      CCDS5532.1
      UniProtKB/Swiss-Prot
      A8MUZ4, A8MW23, B2R4H4, B4E198, O75575, Q3KRA3, Q5HYF1, Q8IXL4
      Related
      ENSP00000378736.3, ENST00000395326.8
      Conserved Domains (1) summary
      smart00657
      Location:1 → 127
      RPOL4c; DNA-directed RNA-polymerase II subunit

    RNA

    1. NR_024548.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an additional exon in the coding region, which includes a translation stop codon, as compared to variant 1. This transcript is therefore a nonsense-mediated mRNA decay (NMD) candidate, and does not make a functional protein.
      Source sequence(s)
      AC068533, BC052570, DA955978
      Related
      ENST00000360415.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      66114818..66154568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      67336904..67376648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75575.1 GenPept UniProtKB/Swiss-Prot:O75575

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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