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    Rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 71330, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rcbtb1provided by MGI
    Official Full Name
    regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1provided by MGI
    Primary source
    MGI:MGI:1918580
    See related
    Ensembl:ENSMUSG00000035469 AllianceGenome:MGI:1918580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLLD7; CLLL7; 5430409I18Rik
    Summary
    Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in genitourinary system. Orthologous to human RCBTB1 (RCC1 and BTB domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.7), CNS E14 (RPKM 14.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C3; 14 31.47 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59438471..59474716)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59201018..59237267)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700129C05 gene Neighboring gene STARR-seq mESC enhancer starr_36836 Neighboring gene predicted gene 5142 Neighboring gene STARR-seq mESC enhancer starr_36837 Neighboring gene PHD finger protein 11 Neighboring gene PHD finger protein 11A Neighboring gene STARR-positive B cell enhancer mm9_chr14:59916339-59916640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases. Plafker KS, et al. Biochemistry, 2009 Apr 21. PMID 19256485, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RCC1 and BTB domain-containing protein 1
    Names
    regulator of chromosome condensation and BTB domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360610.1 → NP_001347539.1  RCC1 and BTB domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166169, BC040764, BC067005, BQ179206
      Consensus CDS
      CCDS27168.1
      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Related
      ENSMUSP00000022551.8, ENSMUST00000022551.14
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    2. NM_001360611.1 → NP_001347540.1  RCC1 and BTB domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166169, AK017287, BC067005, CA325180
      UniProtKB/TrEMBL
      Q9D3M1
      Related
      ENSMUST00000095778.8
      Conserved Domains (1) summary
      cl27697
      Location:30 → 153
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. NM_027764.2 → NP_082040.2  RCC1 and BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082040.2

      Status: VALIDATED

      Source sequence(s)
      AK033501, BC040764, CJ183647
      Consensus CDS
      CCDS27168.1
      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Related
      ENSMUSP00000037030.7, ENSMUST00000043227.13
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      59438471..59474716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248032.2 → XP_030103892.1  RCC1 and BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    2. XM_017316204.3 → XP_017171693.1  RCC1 and BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    3. XM_006519566.4 → XP_006519629.1  RCC1 and BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006519629.1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    4. XM_006519569.4 → XP_006519632.1  RCC1 and BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006519632.1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    5. XM_006519567.4 → XP_006519630.1  RCC1 and BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006519630.1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    6. XM_030248034.2 → XP_030103894.1  RCC1 and BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    7. XM_030248033.2 → XP_030103893.1  RCC1 and BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    8. XM_017316205.3 → XP_017171694.1  RCC1 and BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXM2, Q8BTZ6, Q8BZV0
      UniProtKB/TrEMBL
      A0A0R4J025
      Conserved Domains (3) summary
      COG5184
      Location:43 → 316
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18353
      Location:350 → 466
      BTB_POZ_RCBTB1_CLLD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)
      cd18528
      Location:466 → 531
      BACK_RCBTB1; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1)

    RNA

    1. XR_003950902.2 RNA Sequence

    2. XR_004938447.1 RNA Sequence

    3. XR_003950901.2 RNA Sequence

    4. XR_383211.5 RNA Sequence

    5. XR_004938446.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXM2.1 GenPept UniProtKB/Swiss-Prot:Q6NXM2

    Gene LinkOut

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