STE14A S-isoprenylcysteine O-methyltransferase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: STE14A
Gene description: S-isoprenylcysteine O-methyltransferase
Primary source: Araport:AT5G23320
Locus tag: AT5G23320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA ISOPRENYL CYSTEINE METHYLTRANSFERASE A; ATICMTA; ATPCM; ATSTE14; ATSTE14A; homolog of yeast STE14 A; ICMTA; ISOPRENYL CYSTEINE METHYLTRANSFERASE A; LPHA-CARBOXYL METHYLTRANSFERASE; MKD15.18; MKD15_18; PRENYLCYSTEINE ALPHA-CARBOXYL METHYLTRANSFERASE; STE14
Summary: Encodes a prenylcysteine alpha-carboxyl methyltransferase involved in methylation of isoprenylated proteins. This protein appears to have lower catalytic activity and a lower transcript expression level than the other ICMT present in Arabidopsis (At5g08335). Analysis of ICMT RNAi lines suggests that this protein may be involved in flower and stem development.
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Genomic context

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See STE14A in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (7852585..7853963)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observations support the hypothesis that the ABA hypersensitive phenotype of fcly plants is the result of FC accumulation and inhibition of ICMT.
Title: Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.
phenotype of RNAi lines is similar to farnesyltransferase beta-subunit mutant enhanced response to abscisic acid2 but is more subtle
Title: Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables carboxyl-O-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within C-terminal protein methylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within C-terminal protein methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within shoot system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: S-isoprenylcysteine O-methyltransferase

NP_197723.1

homolog of yeast STE14 A (STE14A); CONTAINS InterPro DOMAIN/s: Isoprenylcysteine carboxyl methyltransferase (InterPro:IPR007269); BEST Arabidopsis thaliana protein match is: Isoprenylcysteine carboxyl methyltransferase (ICMT) family (TAIR:AT5G08335.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

7852585..7853963

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001343798.1 → NP_001330699.1 S-isoprenylcysteine O-methyltransferase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178ULE8, A0A1P8BBN6, A0A5S9Y6S3

Conserved Domains (1) summary

COG2020
Location:41 → 221

STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]
NM_122238.2 → NP_197723.1 S-isoprenylcysteine O-methyltransferase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0MFH5, Q9FMW9

UniProtKB/TrEMBL

A0A178ULE8, A0A654G3P8

Conserved Domains (1) summary

COG2020
Location:16 → 196

STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]