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    apaf1.L apoptotic peptidase activating factor 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444261, updated on 11-Apr-2024

    Summary

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    Official Symbol
    apaf1.L
    Official Full Name
    apoptotic peptidase activating factor 1 L homeolog
    Primary source
    Xenbase:XB-GENE-988971
    Locus tag
    XELAEV_18017354mg
    See related
    EnsemblRapid:ENSXLAG00005006456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    apaf1; apaf-1
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    Genomic context

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    Location:
    chromosome: 3L
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (55576169..55622800, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (41123732..41170112, complement)

    Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 2 L homeolog Neighboring gene early growth response 1 L homeolog Neighboring gene coiled-coil domain containing 87 L homeolog Neighboring gene t-complex 11, testis-specific-like 2 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC80868

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of apoptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    apoptotic peptidase activating factor 1 L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092365.1 → NP_001085834.1  apoptotic peptidase activating factor 1 L homeolog

      See identical proteins and their annotated locations for NP_001085834.1

      Status: PROVISIONAL

      Source sequence(s)
      BC073405
      UniProtKB/TrEMBL
      A0A974DB56, Q6GNU6
      Related
      ENSXLAP00005019194.1, ENSXLAT00005019529.1
      Conserved Domains (5) summary
      COG2319
      Location:651 → 1033
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:610 → 906
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd08323
      Location:7 → 92
      CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
      pfam00931
      Location:129 → 409
      NB-ARC; NB-ARC domain
      sd00039
      Location:623 → 655
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      55576169..55622800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041585085.1 → XP_041441019.1  apoptotic peptidase activating factor 1 L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1MH22, A0A974DB56
      Conserved Domains (3) summary
      cd00200
      Location:610 → 905
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd08323
      Location:7 → 92
      CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
      sd00039
      Location:660 → 697
      7WD40; WD40 repeat [structural motif]

    2. XM_041585084.1 → XP_041441018.1  apoptotic peptidase activating factor 1 L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1MH22, A0A974DB56
      Conserved Domains (3) summary
      cd00200
      Location:610 → 905
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd08323
      Location:7 → 92
      CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
      sd00039
      Location:660 → 697
      7WD40; WD40 repeat [structural motif]

    3. XM_041585083.1 → XP_041441017.1  apoptotic peptidase activating factor 1 L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1MH22, A0A974DB56
      Conserved Domains (3) summary
      cd00200
      Location:610 → 905
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd08323
      Location:7 → 92
      CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
      sd00039
      Location:660 → 697
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_005965999.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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