ALR1 Mg(2+) transporter ALR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ALR1
Gene description: Mg(2+) transporter ALR1
Primary source: SGD:S000005490
Locus tag: YOL130W
See related: AllianceGenome:SGD:S000005490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SWC3
Summary: Enables inorganic cation transmembrane transporter activity. Involved in magnesium ion transport. Located in plasma membrane. Used to study primary hypomagnesemia. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (74400..76979)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alr1 is required for the up-regulation of the Mg(2+) content in polyamine-depleted cells
Title: Elevation of cellular Mg(2+) levels by the Mg(2+) transporter, Alr1, supports growth of polyamine-deficient Saccharomyces cerevisiae cells.
Superoxide is released at the level of Erv/ALR monomers and does not require the obligatory involvement of dimeric forms of these proteins as they reduce the superoxide ion and release up to ~30% of the oxygen.
Title: Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover.
Data conclude that variation in Alr1 protein accumulation or location does not make a substantial contribution to its regulation by Mg supply, suggesting Alr1 activity is directly regulated via as yet unknown mechanisms.
Title: Regulation of Alr1 Mg transporter activity by intracellular magnesium.
High expression of inactive mutants inhibited the capability of wild-type Alr1 to transport magnesium, consistent with Alr1 forming homo-oligomers. The results confirm the classification of ALR1 as a member of the CorA family of magnesium transport genes.
Title: Residues of the yeast ALR1 protein that are critical for magnesium uptake.
Alr1p and Alr2p are shown here to be present in the plasma membrane and shown to form homo-oligomers as well as hetero-oligomers; both the N-terminus and C-terminus of Alr1p and Alr2p are exposed to the inner side of the plasma membrane
Title: Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inorganic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in magnesium ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Mg(2+) transporter ALR1

NP_014511.1

Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

74400..76979

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183384.1 → NP_014511.1 TPA: Mg(2+) transporter ALR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014511.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1T8, Q02811, Q08269

UniProtKB/TrEMBL

A0A8H4BWI5, B5VRC8, C7GV06, N1NYL1

Conserved Domains (1) summary

cd12829
Location:456 → 779

Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily