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    AQY1 Aqy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856322, updated on 27-Jan-2024

    Summary

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    Gene symbol
    AQY1
    Gene description
    Aqy1p
    Primary source
    SGD:S000006396
    Locus tag
    YPR192W
    See related
    AllianceGenome:SGD:S000006396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables water channel activity. Involved in ascospore formation; transmembrane transport; and water transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Bothnian type palmoplantar keratoderma; cataract (multiple); nephrogenic diabetes insipidus; optic nerve disease (multiple); and transverse myelitis. Orthologous to several human genes including AQP1 (aquaporin 1 (Colton blood group)) and AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (921860..922777)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit C82 Neighboring gene ubiquinol--cytochrome-c reductase subunit 2 Neighboring gene histone acetyltransferase Neighboring gene Opt2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. Rodrigues C, et al. IUBMB Life, 2017 May. PMID 28337841
    2. Subangstrom resolution X-ray structure details aquaporin-water interactions. Eriksson UK, et al. Science, 2013 Jun 14. PMID 23766328, Free PMC Article
    3. The Saccharomyces cerevisiae aquaporin Aqy1 is involved in sporulation. Sidoux-Walter F, et al. Proc Natl Acad Sci U S A, 2004 Dec 14. PMID 15583134, Free PMC Article
    4. Molecular and functional study of AQY1 from Saccharomyces cerevisiae: role of the C-terminal domain. Laizé V, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092523
    5. General factors important for the formation of structured biofilm-like yeast colonies. St'ovíček V, et al. Fungal Genet Biol, 2010 Dec. PMID 20728557

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AQY1 role in oxidative stress response and its regulation by 4-hydroxynonenal
      Title: Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response.
    2. Several genomic signatures at AQY1 and/or AQY2 reveal low variation surrounding these loci within strains of the same haplotype, but high variation between strain groups
      Title: Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisiae populations.
    3. Studies show that by using CYS4 as a covariate and conducted both single- and combined-cross linkage mapping, AQY1 and MKT1 were found to have drug-specific and background-dependent effects.
      Title: A combined-cross analysis reveals genes with drug-specific and background-dependent effects on drug sensitivity in Saccharomyces cerevisiae.
    4. Aqy1 is developmentally controlled and may play a role in spore maturation, probably by allowing water outflow
      Title: The Saccharomyces cerevisiae aquaporin Aqy1 is involved in sporulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables water channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in water transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aqy1p
    NP_015518.1
    • Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      921860..922777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184289.1 → NP_015518.1  TPA: Aqy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J2, O74680, P0CD91, P53386
      UniProtKB/TrEMBL
      D3W789, D3W7A4, N1NW73
      Conserved Domains (1) summary
      TIGR00861
      Location:54 → 266
      MIP; MIP family channel proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CD91.1

    Gene LinkOut

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