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    MDL2 ATP-binding cassette permease MDL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855858, updated on 25-Apr-2024

    Summary

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    Gene symbol
    MDL2
    Gene description
    ATP-binding cassette permease MDL2
    Primary source
    SGD:S000006191
    Locus tag
    YPL270W
    See related
    AllianceGenome:SGD:S000006191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ABC-type oligopeptide transporter activity. Involved in cellular response to hydrogen peroxide. Located in mitochondrial inner membrane. Colocalizes with vacuolar membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (30482..32803)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pbi1p Neighboring gene F1F0 ATP synthase subunit epsilon Neighboring gene Kar9p Neighboring gene phosphatidylinositol phospholipase C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Dean M, et al. Yeast, 1994 Mar. PMID 7912468
    2. Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters. Park K, et al. FEBS Lett, 2014 Sep 17. PMID 25128661
    3. Role of the ABC transporter Mdl1 in peptide export from mitochondria. Young L, et al. Science, 2001 Mar 16. PMID 11251115
    4. Proteome-wide signatures of function in highly diverged intrinsically disordered regions. Zarin T, et al. Elife, 2019 Jul 2. PMID 31264965, Free PMC Article
    5. Identification new potential multidrug resistance proteins of Saccharomyces cerevisiae. Grechko VM, et al. J Microbiol Methods, 2020 Sep. PMID 32795632

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modes of insertion into the mitochondrial membrane of individual segments of Mdl1 and Mdl2 differ and is dependent on domain sequence context.
      Title: Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type oligopeptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type oligopeptide transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligopeptide export from mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligopeptide export from mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette permease MDL2
    NP_015053.2
    • Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      30482..32803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184084.1 → NP_015053.2  TPA: ATP-binding cassette permease MDL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015053.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3A0, P33311, Q08983
      UniProtKB/TrEMBL
      A0A6V8S377, A6ZVY6, B3LKG3, G2WNR6
      Conserved Domains (1) summary
      TIGR00958
      Location:1 → 685
      3a01208; Conjugate Transporter-2 (CT2) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33311.3

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