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    AFB1 Afb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850730, updated on 15-Oct-2023

    Summary

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    Gene symbol
    AFB1
    Gene description
    Afb1p
    Primary source
    SGD:S000004030
    Locus tag
    YLR040C
    See related
    AllianceGenome:SGD:S000004030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in response to pheromone triggering conjugation with cellular fusion. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (228908..229582, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIb Neighboring gene Ric1p Neighboring gene Nfg1p Neighboring gene thioredoxin TRX1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome Profiling for Aflatoxin B(1) Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B(1)-Associated DNA Damage. St John N, et al. G3 (Bethesda), 2020 Nov 5. PMID 32994210, Free PMC Article
    2. Genetically engineered transvestites reveal novel mating genes in budding yeast. Huberman LB, et al. Genetics, 2013 Dec. PMID 24121774, Free PMC Article
    3. Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae. Galgoczy DJ, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15604142, Free PMC Article
    4. High-resolution view of the yeast meiotic program revealed by ribosome profiling. Brar GA, et al. Science, 2012 Feb 3. PMID 22194413, Free PMC Article
    5. Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins. Hamada K, et al. J Bacteriol, 1999 Jul. PMID 10383953, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to pheromone triggering conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to pheromone triggering conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Afb1p
    NP_013141.1
    • MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      228908..229582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181927.1 → NP_013141.1  TPA: Afb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY43, Q07988
      UniProtKB/TrEMBL
      A0A8H4BXY1, A7A0U6, B3LT12, B5VMX4, C7GU49, C8ZD12, G2WIN3, N1P040
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07988.1

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