U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hfw halfway [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31120, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hfwprovided by FlyBase
    Official Full Name
    halfwayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001189
    Locus tag
    Dmel_CG3095
    See related
    AllianceGenome:FB:FBgn0001189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3095; CT10406; Dmel\CG3095; EG:171E4.2; l(1)2Bf; l(1)nfw; swi; SWI
    Summary
    Involved in intracellular signal transduction; pupariation; and response to ecdysone. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; gut section; and visceral muscle primordium. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hfw in Genome Data Viewer
    Location:
    2B5-2B6; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1669570..1673608)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1563603..1567641)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mucin related 2B Neighboring gene broad Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene deep orange Neighboring gene uncharacterized protein Neighboring gene b6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Testing odor response stereotypy in the Drosophila mushroom body. Murthy M, et al. Neuron, 2008 Sep 25. PMID 18817738, Free PMC Article
    2. [Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin]. Mazina MIu, et al. Tsitologiia, 2013. PMID 23875451
    3. Linking histone acetylation to transcriptional regulation. Mizzen CA, et al. Cell Mol Life Sci, 1998 Jan. PMID 9487383, Free PMC Article
    4. [Comparison of the molecular and genetic map of the 2B6-2B7-8 of Drosophila melanogaster X-chromosome]. Makunin IV, et al. Genetika, 1999 Aug. PMID 10546111
    5. Chromatin remodeling machines: similar motors, ulterior motives. Cairns BR. Trends Biochem Sci, 1998 Jan. PMID 9478131

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insulator protein Su(Hw) recruits histone acetyltransferase complex SAGA and chromatin remodeler dSWI/SNF to Su(Hw)-dependent insulators and creates platform for origin recognition complex binding.
      Title: [Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin].
    2. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs.
      Title: SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster.
    3. Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
      Title: Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    halfway
    Names
    CG3095-PA
    CG3095-PB
    hfw-PA
    hfw-PB
    singed wings
    singed-wings

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1669570..1673608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272206.1 → NP_001259135.1  halfway, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46061, Q8SZE5, Q9W568
      UniProtKB/TrEMBL
      B6IDK2, F0JAN4
      Conserved Domains (2) summary
      sd00031
      Location:237 → 259
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:235 → 294
      LRR_8; Leucine rich repeat

    2. NM_130577.4 → NP_569933.2  halfway, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569933.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46061, Q8SZE5, Q9W568
      UniProtKB/TrEMBL
      B6IDK2, F0JAN4
      Related
      FBpp0070260
      Conserved Domains (2) summary
      sd00031
      Location:237 → 259
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:235 → 294
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6IDK2 B6IDK2
    Q9W568.3 Q9W568

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous