Glp2r glucagon-like peptide 2 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glp2rprovided by MGI
Official Full Name: glucagon-like peptide 2 receptorprovided by MGI
Primary source: MGI:MGI:2136733
See related: Ensembl:ENSMUSG00000049928 AllianceGenome:MGI:2136733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLP-2; 9530092J08Rik
Summary: Predicted to enable glucagon receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in foregut-midgut junction; hindgut; midgut; and rectum. Orthologous to human GLP2R (glucagon like peptide 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 2.5), colon adult (RPKM 1.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.13 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67554877..67661979, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67664156..67771184, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
Title: Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
GPR40 activation ameliorates DSS-induced colitis in mice by enhancing GLP-2 production.
Title: G protein-coupled receptor 40 activation ameliorates dextran sulfate sodium-induced colitis in mice via the upregulation of glucagon-likepeptide-2.
Lack of Glp2r appears to interfere with VLDL secretion, resulting in enhanced hepatic lipid accumulation.
Title: GLP-2 Dysregulates Hepatic Lipoprotein Metabolism, Inducing Fatty Liver and VLDL Overproduction in Male Hamsters and Mice.
These results suggest that PAS-CPPs-GLP-2 is effective for i.n. delivery to the brain, and may be useful in the clinical treatment of major depression
Title: Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice.
Results suggest that GLP-2 protected and improved memory function in LPS-treated mice, and also had anxiolytic effects due to changes in the 5-HT system.
Title: Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice.
Report gastrointestinal GLP-2 receptor andl limited utility of GLP-2 in the management of inflammatory intestinal disorders.
Title: Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
GLP-2 plays a key physiological role in the control of hepatic glucose production through activating PI3K-dependent modulation of membrane excitability and nuclear transcription of POMC neurons in the brain.
Title: Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons.
Data suggest a role for endogenous GLP2 (glucagon-like peptide-2) and GLP2R in adaptation of mucosa of duodenum and jejunum to high-fat diet; results suggest dysregulation of GLP2/GLP2R signaling in obesity due to prolonged high-fat diet.
Title: Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet.
The data indicated that CNS GLP-2 receptor plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system.
Title: GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility.
Data suggest that the Vip gene is not required for induction of a gene expression program linked to small bowel growth after enhancement of GLP-2 receptor signaling.
Title: Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucagon-like peptide 2 receptor

Names: G protein-coupled receptor GLP2R; GLP-2 receptor; GLP-2-R; GLP-2R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175681.3 → NP_783612.2 glucagon-like peptide 2 receptor precursor

See identical proteins and their annotated locations for NP_783612.2

Status: VALIDATED

Source sequence(s)

AL646097, BC044746

Consensus CDS

CCDS24860.1

UniProtKB/Swiss-Prot

Q5IXF8, Q5SU65

UniProtKB/TrEMBL

A0A158RFU9

Related

ENSMUSP00000061560.9, ENSMUST00000051765.9

Conserved Domains (2) summary

pfam00002
Location:137 → 394

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:53 → 122

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

67554877..67661979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534562.5 → XP_006534625.1 glucagon-like peptide 2 receptor isoform X2

Conserved Domains (3) summary

cd14964
Location:139 → 164

7tm_GPCRs; TM helix 1 [structural motif]

pfam02793
Location:53 → 122

HRM; Hormone receptor domain

cl28897
Location:137 → 405

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006534561.5 → XP_006534624.1 glucagon-like peptide 2 receptor isoform X1

Conserved Domains (3) summary

cd14964
Location:139 → 164

7tm_GPCRs; TM helix 1 [structural motif]

pfam02793
Location:53 → 122

HRM; Hormone receptor domain

cl28897
Location:137 → 406

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily