MYC3 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: MYC3
Gene description: Basic helix-loop-helix (bHLH) DNA-binding family protein
Primary source: Araport:AT5G46760
Locus tag: AT5G46760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MZA15.18; MZA15_18
Summary: MYC3 is a JAZ-interacting transcription factor that act together with MYC2 and MYC4 to activate JA-responses.
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Genomic context

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See MYC3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (18974022..18976590)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein-protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain.
Title: Protein-protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain.
MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
Title: MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
The function of MYC2, MYC3, and MYC4 in seed development and seed storage protein accumulation
Title: MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis.
JAZ1 and JAZ10 were the only JAZ proteins still showing interaction with the mutant MYC proteins, due to a second MYC interaction domain, besides the classical Jas domain.
Title: Change of a conserved amino acid in the MYC2 and MYC3 transcription factors leads to release of JAZ repression and increased activity.
regulator of glucosinolate biosynthesis
Title: bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis.
MYC3 undergoes pronounced conformational changes when bound to the conserved Jas motif of the JAZ9 repressor
Title: Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes.
Title: Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior.
MYC3 and MYC4, act additively with MYC2 in the activation of jasmonic acid responses.
Title: The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses.
results suggest that MYC3 (At5g46760) and MYC4 are JAZ-interacting transcription factors that regulate jasmonate responses
Title: Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_124046.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular ATP signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal complex development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Basic helix-loop-helix (bHLH) DNA-binding family protein

NP_199488.1

Basic helix-loop-helix (bHLH) DNA-binding family protein; FUNCTIONS IN: protein binding, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: Basic helix-loop-helix (bHLH) DNA-binding family protein (TAIR:AT4G17880.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

18974022..18976590

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124046.2 → NP_199488.1 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W2F5, Q9FIP9

UniProtKB/TrEMBL

A0A654G8W1

Conserved Domains (2) summary

cd00083
Location:414 → 465

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14215
Location:52 → 231

bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal