HB-8 homeobox-leucine zipper protein ATHB-8 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: HB-8
Gene description: homeobox-leucine zipper protein ATHB-8
Primary source: Araport:AT4G32880
Locus tag: AT4G32880
See related: TAIR:AT4G32880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATHB-8; ATHB8; homeobox gene 8; T16I18.90; T16I18_90
Summary: member of homeodomain-leucine zipper family, acting as a differentiation-promoting transcription factor of the vascular meristems.
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Genomic context

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See HB-8 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 18

Sequence:: Chromosome: 4; NC_003075.7 (15863339..15868650, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Congruence between SHR and ATHB8 expression domains persists under conditions of manipulated vein patterning, suggesting that inception of expression of SHR and ATHB8 identifies transition to a preprocambial cell state that presages vein formation.
Title: Simultaneous activation of SHR and ATHB8 expression defines switch to preprocambial cell state in Arabidopsis leaf development.
Data show that the expression of 3 DOF genes DOF2.1 (At2g28510), DOF4.6 (At4g24060) and DOF5.3 (At5g60200) is activated at early vascular development stages overlapping onset of ATHB8 expression.
Title: Expression of DOF genes identifies early stages of vascular development in Arabidopsis leaves.
Here we discuss putative mechanisms by which wide domains of MP expression could activate ATHB8 transcription in single cell files.
Title: Auxin signal transduction in Arabidopsis vein formation.
Class III HD-Zip AND KANADI genes required for root development [ATHB8]
Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119441.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within meristem initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primary shoot apical meristem specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within procambium histogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: homeobox-leucine zipper protein ATHB-8

NP_195014.1

homeobox gene 8 (HB-8); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT1G52150.1); Has 3304 Blast hits to 3224 proteins in 267 species: Archae - 0; Bacteria - 6; Metazoa - 860; Fungi - 101; Plants - 2302; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15863339..15868650 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119441.5 → NP_195014.1 homeobox-leucine zipper protein ATHB-8 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195014.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39123

UniProtKB/TrEMBL

A0A178UUJ8, A0A5S9XYI2

Conserved Domains (4) summary

cd08875
Location:154 → 369

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:67 → 106

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:15 → 73

Homeobox; Homeobox domain

pfam08670
Location:692 → 832

MEKHLA; MEKHLA domain