LAF1 myb domain protein 18 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: LAF1
Gene description: myb domain protein 18
Primary source: Araport:AT4G25560
Locus tag: AT4G25560
See related: TAIR:AT4G25560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtMYB18; LONG AFTER FAR-RED LIGHT 1; M7J2.70; M7J2_70; myb domain protein 18; MYB18
Summary: LAF1 is a R2R3-MYB transcription factor and positive regulator of the phyA photoresponse. Interaction of LAF1 with HFR1 stabilize the proteins against ubiquitination by COP1(AT2G32950) and subsequent degrations. Mutants have an elongated hypocotyl specifically under far-red light but retain wild-type responses to other light wavelengths.
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Genomic context

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See LAF1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (13052503..13053742)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HY5 transmits phyA signals through an FHY1/FHL-independent pathway but it may also modulate FHY1/FHL signal through its interaction with HFR1 and LAF1.[LAF1]
Title: Three transcription factors, HFR1, LAF1 and HY5, regulate largely independent signaling pathways downstream of phytochrome A.
in addition to their independent functions in phyA signaling, LAF1 and HFR1 also cooperate post-translationally to stabilize each other through inhibition of ubiquitination by COP1, thereby enhancing phyA photoresponses
Title: Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001341750.1

Supported by ESTs:

NM_118688.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within far-red light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to red or far red light	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: myb domain protein 18

NP_194286.1

myb domain protein 18 (MYB18); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 19 (TAIR:AT5G52260.1); Has 8724 Blast hits to 8053 proteins in 477 species: Archae - 0; Bacteria - 8; Metazoa - 744; Fungi - 438; Plants - 5747; Viruses - 4; Other Eukaryotes - 1783 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13052503..13053742

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118688.3 → NP_194286.1 myb domain protein 18 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194286.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M0K4, Q9SUI1, Q9ZTF0

UniProtKB/TrEMBL

A0A178V3M0, A0A5S9XVW0, A0A654FSP0

Conserved Domains (1) summary

PLN03091
Location:6 → 113

PLN03091; hypothetical protein; Provisional
NM_001341750.1 → NP_001328550.1 myb domain protein 18 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B4Z5