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    AT4G12010 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826809, updated on 15-Feb-2024

    Summary

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    Gene symbol
    AT4G12010
    Gene description
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    Araport:AT4G12010
    Locus tag
    AT4G12010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16J13.80; F16J13_80
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    Genomic context

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    See AT4G12010 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (7196991..7201571, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Cell cycle regulated microtubule associated protein Neighboring gene SNARE associated Golgi protein family Neighboring gene uncharacterized protein Neighboring gene protein kinase family protein Neighboring gene bile acid transporter 5 Neighboring gene ncRNA Neighboring gene A20/AN1-like zinc finger family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita. Warmerdam S, et al. BMC Plant Biol, 2020 Feb 13. PMID 32054439, Free PMC Article
    2. Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles. Lolle S, et al. Cell Host Microbe, 2017 Apr 12. PMID 28407487
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita.
      Title: The TIR-NB-LRR pair DSC1 and WRKY19 contributes to basal immunity of Arabidopsis to the root-knot nematode Meloidogyne incognita.
    2. DSC1 and DSC2 are responsible for autoimmunity in Arabidopsis camta3 mutants. Immunity triggered by DSC1 or DSC2 in tobacco is suppressed by CAMTA3 co-expression.[DSC1]
      Title: Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_117271.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_192938.1
    • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT4G19510.1); Has 31049 Blast hits to 21052 proteins in 960 species: Archae - 20; Bacteria - 2553; Metazoa - 5096; Fungi - 331; Plants - 21936; Viruses - 4; Other Eukaryotes - 1109 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7196991..7201571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117271.3 → NP_192938.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q680A4, Q9SZ66
      UniProtKB/TrEMBL
      A0A178V7S3
      Conserved Domains (2) summary
      sd00033
      Location:645 → 667
      LRR_RI; leucine-rich repeat [structural motif]
      cl27891
      Location:1 → 1143
      LRR_3; Leucine Rich Repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZ66.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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