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    ATG2 autophagy 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821453, updated on 6-Oct-2023

    Summary

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    Gene symbol
    ATG2
    Gene description
    autophagy 2
    Primary source
    Araport:AT3G19190
    Locus tag
    AT3G19190
    See related
    TAIR:AT3G19190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATG2; AUTOPHAGY 2; PEROXISOME UNUSUAL POSITIONING 1; PEUP1
    Summary
    Encodes autophagy-related 2 (ATG2).
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    Genomic context

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    See ATG2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (6639639..6648870)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plastid division protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene uncharacterized protein Neighboring gene DNA repair/recombination protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis. Jiang Z, et al. Int J Mol Sci, 2020 Jun 25. PMID 32630439, Free PMC Article
    2. ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis. Wang Y, et al. Plant J, 2011 Oct. PMID 21645148
    3. Autophagy-related (ATG) 11, ATG9 and the phosphatidylinositol 3-kinase control ATG2-mediated formation of autophagosomes in Arabidopsis. Kang S, et al. Plant Cell Rep, 2018 Apr. PMID 29350244
    4. Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Hackenberg T, et al. Plant Cell, 2013 Nov. PMID 24285797, Free PMC Article
    5. Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Yoshimoto K, et al. Plant Cell, 2009 Sep. PMID 19773385, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
      Title: Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
    2. Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis.
      Title: Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis.
    3. After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
      Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.
    4. Data suggest that PI3K, ATG11 and ATG9 act upstream of ATG2 in Arabidopsis.
      Title: Autophagy-related (ATG) 11, ATG9 and the phosphatidylinositol 3-kinase control ATG2-mediated formation of autophagosomes in Arabidopsis.
    5. The atg2-2 mutant showed enhanced resistance to powdery mildew and dramatic mildew-induced cell death as well as early senescence phenotypes in the absence of pathogens. Defense-related genes were constitutively activated in atg2-2.
      Title: ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112806.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    autophagy 2
    NP_188550.3
    • AUTOPHAGY 2 (ATG2); CONTAINS InterPro DOMAIN/s: autophagy-related, C-terminal (InterPro:IPR015412); Has 828 Blast hits to 713 proteins in 221 species: Archae - 0; Bacteria - 44; Metazoa - 384; Fungi - 228; Plants - 88; Viruses - 0; Other Eukaryotes - 84 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6639639..6648870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338385.1 → NP_001327751.1  autophagy 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LTA0, F4JB41, F8S296, Q9LJK9, Q9LJL0
      UniProtKB/TrEMBL
      A0A178V901

    2. NM_001338386.1 → NP_001327752.1  autophagy 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LTA0, F4JB41, F8S296, Q9LJK9, Q9LJL0
      UniProtKB/TrEMBL
      A0A178V901

    3. NM_112806.3 → NP_188550.3  autophagy 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188550.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V901
      Conserved Domains (2) summary
      pfam09333
      Location:1725 → 1826
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:39 → 119
      Chorein_N; N-terminal region of Chorein or VPS13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8S296.1

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