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    NAI2 DNA topoisomerase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820839, updated on 6-Oct-2023

    Summary

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    Gene symbol
    NAI2
    Gene description
    DNA topoisomerase-like protein
    Primary source
    Araport:AT3G15950
    Locus tag
    AT3G15950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Similar to TSK-associating protein 1 (TSA1), contains 10 EFE repeats, a novel repeat sequence unique to plants. Expressed preferentially in the roots.Protein is localized to ER bodies- an endoplasmic reticulum derived structure. Loss of function mutations lack ER bodies.
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    Genomic context

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    See NAI2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    28
    Sequence:
    Chromosome: 3; NC_003074.8 (5397541..5402653, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene ncRNA Neighboring gene mismatched DNA binding / ATP binding protein Neighboring gene NUP50 (Nucleoporin 50 kDa) protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NAI2 is an endoplasmic reticulum body component that enables ER body formation in Arabidopsis thaliana. Yamada K, et al. Plant Cell, 2008 Sep. PMID 18780803, Free PMC Article
    2. NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae. Stefanik N, et al. Plant Cell Physiol, 2020 Apr 1. PMID 31879762
    3. At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana. Kumar MN, et al. Proc Natl Acad Sci U S A, 2015 Aug 18. PMID 26240315, Free PMC Article
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. Isolation and identification of ubiquitin-related proteins from Arabidopsis seedlings. Igawa T, et al. J Exp Bot, 2009. PMID 19429840, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae.
      Title: NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae.
    2. AFL1, PDI5, and NAI2 are involved in drought signaling in Arabidopsis thaliana
      Title: At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana.
    3. Data indicate that NAI2 gene (At3g15950) is a key factor that enables ER body formation and the accumulation of PYK10 in ER bodies of Arabidopsis.
      Title: NAI2 is an endoplasmic reticulum body component that enables ER body formation in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035631.2
    NM_001338191.1
    NM_001338192.1
    NM_001338193.1
    NM_112465.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ER body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase-like protein
    NP_001030708.1
    • NAI2; INVOLVED IN: ER body organization, response to salt stress; LOCATED IN: peroxisome, membrane, ER body; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: TSK-associating protein 1 (TAIR:AT1G52410.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_188216.2
    • NAI2; INVOLVED IN: ER body organization, response to salt stress; LOCATED IN: peroxisome, membrane, ER body; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: TSK-associating protein 1 (TAIR:AT1G52410.2); Has 54717 Blast hits to 36231 proteins in 2578 species: Archae - 1044; Bacteria - 11642; Metazoa - 21799; Fungi - 5619; Plants - 2799; Viruses - 308; Other Eukaryotes - 11506 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5397541..5402653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035631.2 → NP_001030708.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F8N8
      Conserved Domains (2) summary
      COG1196
      Location:134 → 469
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12472
      Location:571 → 713
      PRK12472; hypothetical protein; Provisional

    2. NM_112465.4 → NP_188216.2  DNA topoisomerase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188216.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J1D7, Q712H0, Q9LSB4
      UniProtKB/TrEMBL
      A0A178VJ32, A0A5S9XCQ4
      Conserved Domains (2) summary
      COG1196
      Location:117 → 457
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12472
      Location:609 → 751
      PRK12472; hypothetical protein; Provisional

    3. NM_001338193.1 → NP_001326808.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE5

    4. NM_001338192.1 → NP_001326807.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE4, A0A654F8N8

    5. NM_001338191.1 → NP_001326809.1  DNA topoisomerase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQE6, A0A654F8N8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSB4.1

    Gene LinkOut

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