TRXF1 thioredoxin F-type 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: TRXF1
Gene description: thioredoxin F-type 1
Primary source: Araport:AT3G02730
Locus tag: AT3G02730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATF1; thioredoxin F-type 1
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Genomic context

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See TRXF1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (588266..589693, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results reveal the key residues for thioredoxin-f (Trx-f1, Trx-f2) specific target recognition, providing critical insight into redox regulation of photosynthesis.
Title: Impact of key residues within chloroplast thioredoxin-f on recognition for reduction and oxidation of target proteins.
These results show that the function of f-type Thioredoxins in the rapid activation of carbon metabolism in response to light is not entirely compensated for by additional plastid redox systems.
Title: Type-f thioredoxins have a role in the short-term activation of carbon metabolism and their loss affects growth under short-day conditions in Arabidopsis thaliana.
knockout led to strong attenuation in reductive light activation of ADP-glucose pyrophosphorylase in leaves during the day
Title: Inactivation of thioredoxin f1 leads to decreased light activation of ADP-glucose pyrophosphorylase and altered diurnal starch turnover in leaves of Arabidopsis plants.
Results describe the redox regulation of plastidial glucose-6-phosphate dehydrogenase and found that its oxidative activation is strictly dependent on plastidial thioredoxins, including thioredoxin f, that show differential efficiencies.
Title: Redox regulation of chloroplastic glucose-6-phosphate dehydrogenase: a new role for f-type thioredoxin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_111141.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to light intensity	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast thylakoid	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: thioredoxin F-type 1

NP_186922.1

thioredoxin F-type 1 (TRXF1); FUNCTIONS IN: enzyme activator activity; INVOLVED IN: positive regulation of catalytic activity; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin, conserved site (InterPro:IPR017937); BEST Arabidopsis thaliana protein match is: thioredoxin F2 (TAIR:AT5G16400.1); Has 15154 Blast hits to 14708 proteins in 2900 species: Archae - 210; Bacteria - 7832; Metazoa - 1846; Fungi - 908; Plants - 1556; Viruses - 3; Other Eukaryotes - 2799 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

588266..589693 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111141.3 → NP_186922.1 thioredoxin F-type 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M8R5, Q9XFH8

UniProtKB/TrEMBL

A0A178VBJ7, A0A5S9X8J1, A0A7G2ELU9

Conserved Domains (1) summary

cd02947
Location:76 → 170

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...