NRT1:2 nitrate transporter 1:2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: NRT1:2
Gene description: nitrate transporter 1:2
Primary source: Araport:AT1G69850
Locus tag: AT1G69850
See related: TAIR:AT1G69850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABA-importing transporter 1; AIT1; AtNPF4.6; ATNRT1:2; nitrate transporter 1:2; NPF4.6; NRT1.2; NRT1/ PTR family 4.6; NTL1; T17F3.12; T17F3_12
Summary: Encodes an inducible component of low-affinity nitrate uptake. mRNA found primarily in root hairs and the epidermis of roots. It also acts as an ABA importer at the site of ABA biosynthesis and is important for the regulation of stomatal aperture in inflorescence stems.
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Genomic context

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See NRT1:2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (26296540..26300684, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis NPF4.6 and NPF5.1 Control Leaf Stomatal Aperture by Regulating Abscisic Acid Transport.
Title: Arabidopsis NPF4.6 and NPF5.1 Control Leaf Stomatal Aperture by Regulating Abscisic Acid Transport.
Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
Title: Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis.
Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dalpha1 (PLDalpha1) to positively regulate seed germination and seedling development in response to ABA treatment.
Title: Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dα1 (PLDα1) to positively regulate seed germination and seedling development in response to ABA treatment.
Abscisic acid (ABA)-importing transporter 1 (AIT1) contributes to the inhibition of Cd accumulation via exogenous ABA application in Arabidopsis.
Title: Abscisic acid (ABA)-importing transporter 1 (AIT1) contributes to the inhibition of Cd accumulation via exogenous ABA application in Arabidopsis.
These results do not support the idea of a physiological linkage between nitrate and ABA signals through AtNPF4.6.
Title: Nitrate does not compete with abscisic acid as a substrate of AtNPF4.6/NRT1.2/AIT1 in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_105653.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables abscisic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nitrate transporter 1:2

NP_564978.1

nitrate transporter 1:2 (NRT1:2); FUNCTIONS IN: transporter activity, calcium ion binding; INVOLVED IN: response to nematode; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT1G27040.1); Has 5870 Blast hits to 5639 proteins in 1033 species: Archae - 0; Bacteria - 2327; Metazoa - 503; Fungi - 400; Plants - 2186; Viruses - 0; Other Eukaryotes - 454 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

26296540..26300684 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105653.5 → NP_564978.1 nitrate transporter 1:2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564978.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81393, Q8H157, Q8W4N9, Q9CAR8

UniProtKB/TrEMBL

A0A178W7G0, A0A5S9WR62, A0A654EP98

Conserved Domains (1) summary

cd17414
Location:29 → 575

MFS_NPF4; NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters