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    AT1G65030 Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842811, updated on 15-Feb-2024

    Summary

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    Gene symbol
    AT1G65030
    Gene description
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    Araport:AT1G65030
    Locus tag
    AT1G65030
    See related
    TAIR:AT1G65030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16G16.2; F16G16_2
    Summary
    This gene is predicted to encode a protein with a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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    Genomic context

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    See AT1G65030 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (24156672..24158675)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box only protein Neighboring gene WEB family protein (DUF827) Neighboring gene plasma protein Neighboring gene COMPLEX 1 LYR-like protein Neighboring gene RING/U-box superfamily protein Neighboring gene TRAF-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    2. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Multi-omics network-based functional annotation of unknown Arabidopsis genes. Depuydt T, et al. Plant J, 2021 Nov. PMID 34562334
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105177.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_176683.1
    • Transducin/WD40 repeat-like superfamily protein; FUNCTIONS IN: protein binding, nucleotide binding; LOCATED IN: nucleolus, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); Has 5965 Blast hits to 4406 proteins in 385 species: Archae - 22; Bacteria - 1754; Metazoa - 1570; Fungi - 1477; Plants - 405; Viruses - 0; Other Eukaryotes - 737 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24156672..24158675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105177.5 → NP_176683.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W155, Q5XEV4, Q8H177
      Conserved Domains (2) summary
      sd00039
      Location:45 → 81
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:39 → 319
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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