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    ACLA-2 ATP-citrate lyase A-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842375, updated on 7-Sep-2023

    Summary

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    Gene symbol
    ACLA-2
    Gene description
    ATP-citrate lyase A-2
    Primary source
    Araport:AT1G60810
    Locus tag
    AT1G60810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-citrate lyase A-2; F8A5.32; F8A5_32
    Summary
    One of the three genes encoding subunit A of the trimeric enzyme ATP Citrate lyase
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    Genomic context

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    See ACLA-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (22388527..22391237, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene NSP-interacting kinase 3 Neighboring gene RALF-like 7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Fatland BL, et al. Plant Physiol, 2002 Oct. PMID 12376641, Free PMC Article
    2. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333917.1
    NM_104764.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP citrate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-dependent citrate lyase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ATP-citrate lyase A-2
    NP_176280.1
    • ATP-citrate lyase A-2 (ACLA-2); CONTAINS InterPro DOMAIN/s: ATP-grasp fold, subdomain 2 (InterPro:IPR013816), ATP-grasp fold, succinyl-CoA synthetase-type (InterPro:IPR013650), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: ATP-citrate lyase A-1 (TAIR:AT1G10670.4); Has 5556 Blast hits to 5555 proteins in 1577 species: Archae - 133; Bacteria - 3078; Metazoa - 348; Fungi - 198; Plants - 97; Viruses - 0; Other Eukaryotes - 1702 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22388527..22391237 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104764.4 → NP_176280.1  ATP-citrate lyase A-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22718, Q8RXG2, Q9C6C0
      UniProtKB/TrEMBL
      A0A178WJG4, A0A5S9WR04
      Conserved Domains (3) summary
      PLN02235
      Location:1 → 423
      PLN02235; ATP citrate (pro-S)-lyase
      pfam16114
      Location:244 → 418
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:5 → 202
      ATP-grasp_4; ATP-grasp domain

    2. NM_001333917.1 → NP_001320572.1  ATP-citrate lyase A-2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22718, Q8RXG2, Q9C6C0
      UniProtKB/TrEMBL
      A0A178WJG4, A0A5S9WR04
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22718.1

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