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    MAP3KA mitogen-activated protein kinase kinase kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841792, updated on 15-Oct-2023

    Summary

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    Gene symbol
    MAP3KA
    Gene description
    mitogen-activated protein kinase kinase kinase 3
    Primary source
    Araport:AT1G53570
    Locus tag
    AT1G53570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22G10.18; MAP KINASE KINASE KINASE 3; MAPKKK3; MEK KINASE; mitogen-activated protein kinase kinase kinase 3
    Summary
    MEK kinase (MAP3Ka)
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (19987117..19991214)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box family protein Neighboring gene Ribosomal protein L18ae family Neighboring gene glyoxalase II 3 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis. Bi G, et al. Plant Cell, 2018 Jul. PMID 29871986, Free PMC Article
    2. The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation. Yamada K, et al. EMBO J, 2016 Nov 15. PMID 27679653, Free PMC Article
    3. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036104.2
    NM_001198282.1
    NM_001198283.1
    NM_001333598.1
    NM_104235.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pattern recognition receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 3
    NP_001031181.1
    • mitogen-activated protein kinase kinase kinase 3 (MAP3KA); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001185211.1
    • mitogen-activated protein kinase kinase kinase 3 (MAP3KA); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1).
    NP_001185212.1
    • mitogen-activated protein kinase kinase kinase 3 (MAP3KA); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1).
    NP_564635.1
    • mitogen-activated protein kinase kinase kinase 3 (MAP3KA); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1); Has 133768 Blast hits to 131661 proteins in 5018 species: Archae - 142; Bacteria - 15067; Metazoa - 50668; Fungi - 13071; Plants - 32592; Viruses - 564; Other Eukaryotes - 21664 (source: NCBI BLink).
    NP_849803.1
    • mitogen-activated protein kinase kinase kinase 3 (MAP3KA); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1); Has 133847 Blast hits to 131736 proteins in 5019 species: Archae - 142; Bacteria - 15068; Metazoa - 50711; Fungi - 13073; Plants - 32617; Viruses - 564; Other Eukaryotes - 21672 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19987117..19991214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333597.1 → NP_001322087.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AT18, A0A7G2E0T8
      Conserved Domains (1) summary
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    2. NM_179472.3 → NP_849803.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E0T8, A0A7G2E4A8
      Conserved Domains (1) summary
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    3. NM_104235.4 → NP_564635.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564635.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HRJ4, F4HRJ5, F4HRJ8, O82649, Q56ZS2, Q8W582, Q9LPH2, Q9ZRF7
      UniProtKB/TrEMBL
      A0A178WAP6, A0A5S9WPD2, A0A7G2E0T8
      Conserved Domains (1) summary
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    4. NM_001333598.1 → NP_001322088.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASW4, A0A7G2E0T8
      Conserved Domains (1) summary
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    5. NM_001036104.2 → NP_001031181.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E0T8, A0A7G2E4A8
      Conserved Domains (1) summary
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    6. NM_001198282.1 → NP_001185211.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E0T8
      Conserved Domains (2) summary
      smart00220
      Location:214 → 470
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06632
      Location:213 → 470
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

    7. NM_001198283.1 → NP_001185212.1  mitogen-activated protein kinase kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E0T8
      Conserved Domains (2) summary
      smart00220
      Location:214 → 444
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06632
      Location:213 → 444
      STKc_MEKK1_plant; Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HRJ4.1

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