NAC012 NAC domain containing protein 12 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: NAC012
Gene description: NAC domain containing protein 12
Primary source: Araport:AT1G32770
Locus tag: AT1G32770
See related: TAIR:AT1G32770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ANAC012; F6N18.15; F6N18_15; NAC domain containing protein 12; NAC SECONDARY WALL THICKENING PROMOTING 3; NST3; SECONDARY WALL-ASSOCIATED NAC DOMAIN 1; SND1
Summary: Encodes SND1, a NAC Domain transcription factor involved in secondary wall biosynthesis in fibers. Expressed specifically in interfascicular fibers and xylary fibers in stems. Expressed in the procambium of stem inflorescences and root. May act as a negative regulator of secondary wall thickening in xylary fibers. Acts redundantly with NST1 to control development of secondary walls in siliques.
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Genomic context

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See NAC012 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (11865229..11867154, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beta-glucuronidase (GUS) reporter analysis in Arabidopsis showed that the SND1 promoter was active in vascular tissues as previously reported and showed interfascicular and xylary fibre-specific expression in inflorescence stems, while reporter constructs of the woody plant-derived promoters were partial to the (pro)cambium-phloem and protoxylem.
Title: Analysis of Orthologous SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) Promotor Activity in Herbaceous and Woody Angiosperms.
snd1 knockout seedlings are sensitive to salt stress. SND1 binds directly to the promoter of the ABI4 gene and mediates ABA levels. SND1 activates the Myb46 pathway, fostering lignin biosynthesis and cell wall growth.
Title: Dual role of SND1 facilitates efficient communication between abiotic stress signalling and normal growth in Arabidopsis.
These results demonstrate that NST2 together with SND1 and NST1 regulate secondary wall biosynthesis in fibers of stems.
Title: The Arabidopsis NAC transcription factor NST2 functions together with SND1 and NST1 to regulate secondary wall biosynthesis in fibers of inflorescence stems.
NST3 induced uniform non-striated deposition while VND7 induced striated deposition of secondary walls of the fiber cells, indicating the role of nature of transcriptional factors in secondary wall depositions.
Title: VASCULAR-RELATED NAC-DOMAIN7 directly regulates the expression of a broad range of genes for xylem vessel formation.
SND1 upregulated genes that catalyze lignin biosynthesis.
Title: Arabidopsis VASCULAR-RELATED NAC-DOMAIN6 directly regulates the genes that govern programmed cell death and secondary wall formation during xylem differentiation.
SND1 directly activates MYB83.
Title: MYB83 is a direct target of SND1 and acts redundantly with MYB46 in the regulation of secondary cell wall biosynthesis in Arabidopsis.
NST1 and NST3 regulate the formation of secondary walls in siliques which regulates pod shattering.
Title: NAC transcription factors NST1 and NST3 regulate pod shattering in a partially redundant manner by promoting secondary wall formation after the establishment of tissue identity.
These results demonstrate that MYB46 is a direct target of SND1 and is another key player in the transcriptional network involved in the regulation of secondary wall biosynthesis in Arabidopsis.
Title: The MYB46 transcription factor is a direct target of SND1 and regulates secondary wall biosynthesis in Arabidopsis.
ANAC012 may act as a negative regulator of secondary wall thickening in xylary fibers.
Title: ANAC012, a member of the plant-specific NAC transcription factor family, negatively regulates xylary fiber development in Arabidopsis thaliana.
These results reveal that SND1 is a key transcriptional activator involved in secondary wall biosynthesis in fibers.
Title: SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fruit dehiscence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NAC domain containing protein 12

NP_174554.1

NAC domain containing protein 12 (NAC012); CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein (TAIR:AT2G46770.1); Has 2894 Blast hits to 2888 proteins in 75 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 2894; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11865229..11867154 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103011.2 → NP_174554.1 NAC domain containing protein 12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174554.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LPI7

UniProtKB/TrEMBL

A0A178W7E9, A0A5S9WIB8

Conserved Domains (1) summary

pfam02365
Location:19 → 60

NAM; No apical meristem (NAM) protein