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    LIN2 Coproporphyrinogen III oxidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839489, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LIN2
    Official Full Name
    Coproporphyrinogen III oxidase
    Primary source
    TAIR:AT1G03475
    Locus tag
    AT1G03475
    See related
    Araport:AT1G03475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCPO-I; COPROPORPHYRINOGEN III OXIDASE; CPO; F21B7.10; HEMF1; LESION INITIATION 2
    Summary
    Encodes coproporphyrinogen III oxidase, a key enzyme in the biosynthetic pathway of chlorophyll and heme, a tetrapyrrole pathway. Mutants express cytological and molecular markers associated with the defense responses, usually activated by pathogen infection.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (868853..871308, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene NAC domain containing protein 6 Neighboring gene HXXXD-type acyl-transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis. Guo CY, et al. Plant Cell Rep, 2013 May. PMID 23462936
    2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIN2 negatively regulates resistance to powdery mildew and oomycete pathogens.
      Title: A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100230.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coproporphyrinogen oxidase activity IGI
    Inferred from Genetic Interaction
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrapyrrole biosynthetic process IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    Coproporphyrinogen III oxidase
    NP_171847.4
    • LESION INITIATION 2 (LIN2); FUNCTIONS IN: coproporphyrinogen oxidase activity; INVOLVED IN: tetrapyrrole biosynthetic process; LOCATED IN: apoplast, chloroplast stroma, chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Coproporphyrinogen III oxidase (InterPro:IPR001260), Coproporphyrinogen III oxidase, conserved site (InterPro:IPR018375); BEST Arabidopsis thaliana protein match is: Coproporphyrinogen III oxidase (TAIR:AT4G03205.1); Has 4884 Blast hits to 4875 proteins in 1228 species: Archae - 0; Bacteria - 2144; Metazoa - 115; Fungi - 160; Plants - 86; Viruses - 0; Other Eukaryotes - 2379 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      868853..871308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100230.7 → NP_171847.4  Coproporphyrinogen III oxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171847.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q546I5, Q94JR5, Q9LR75
      UniProtKB/TrEMBL
      A0A178WIW9, A0A5S9SDB9
      Conserved Domains (1) summary
      PLN02873
      Location:116 → 386
      PLN02873; coproporphyrinogen-III oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LR75.1

    Gene LinkOut

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