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    yhbO protein/nucleic acid deglycase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947666, updated on 4-Apr-2024

    Summary

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    Gene symbol
    yhbO
    Gene description
    protein/nucleic acid deglycase 2
    Primary source
    ASAP:ABE-0010361
    Locus tag
    b3153
    See related
    ECOCYC:G7647
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3141
    Summary
    A yhbO mutant is sensitive to heat, oxidative, hyperosmotic, pH, and UV stresses (Abdallah, 2007). [More information is available at EcoGene: EG12784]. YhbO is involved in the response to various stresses. [More information is available at EcoCyc: G7647].
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    Genomic context

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    Sequence:
    NC_000913.3 (3298974..3299492)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene permease family protein YraQ Neighboring gene putative nucleoside-diphosphate-sugar epimerase Neighboring gene putative FMN binding protein YhbP Neighboring gene DNA damage response nuclease YhbQ Neighboring gene putative N-acetyltransferase YhbS Neighboring gene anaerobic ubiquinone biosynthesis accessory factor UbiT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli. Abdallah J, et al. Protein Expr Purif, 2006 Jun. PMID 16380269
    2. Peptidase activity of the Escherichia coli Hsp31 chaperone. Malki A, et al. J Biol Chem, 2005 Apr 15. PMID 15550391
    3. Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL. Richarme G, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29932913
    4. The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. Wilson MA, et al. J Mol Biol, 2005 Oct 28. PMID 16181642
    5. Identification of functional subclasses in the DJ-1 superfamily proteins. Wei Y, et al. PLoS Comput Biol, 2007 Jan 26. PMID 17257049, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Parkinsonism-associated protein DJ-1 and its bacterial homologs deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL function as deglycases that repair proteins and nucleotides from endogeneous glycation by glyoxal and methylglyoxal. DJ-1, deglycase 1 and deglycase 2 repair glyoxal- and methylglyoxal-glycated substrates, whereas deglycase 3 principally repairs glyoxal-glycated substrates.
      Title: Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL.
    2. Purified YajL, YhbO and ElbB exhibited glyoxalase activity with different substrate specificities, optimal pHs and metal effects.
      Title: Characterization of the Escherichia coli YajL, YhbO and ElbB glyoxalases.
    3. Moreover, yhbO and yajL mutants display decreased viability in methylglyoxal- or glucose-containing media
      Title: The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal.
    4. YhbO affects a central process in stress management.
      Title: YhbO protects cells against multiple stresses.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glyoxalase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein deglycase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein deglycase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within guanine deglycation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process to lactate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein/nucleic acid deglycase 2
    NP_417622.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3298974..3299492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417622.2 protein/nucleic acid deglycase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417622.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WX51
      Conserved Domains (1) summary
      TIGR01382
      Location:4 → 171
      PfpI; intracellular protease, PfpI family
    Nucleotide Protein
    Heading Accession and Version

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