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    uxuA D-mannonate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947082, updated on 4-Feb-2024

    Summary

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    Gene symbol
    uxuA
    Gene description
    D-mannonate dehydratase
    Primary source
    ASAP:ABE-0014173
    Locus tag
    b4322
    See related
    ECOCYC:EG11066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4313
    Summary
    UxuR regulon. [More information is available at EcoGene: EG11066]. Mannonate dehydratase catalyzes the final reaction of the glucuronate branch of the hexuronate degradation pathway . [More information is available at EcoCyc: EG11066].
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    Genomic context

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    Sequence:
    NC_000913.3 (4551636..4552820)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene type 1 fimbriae D-mannose specific adhesin Neighboring gene fructuronate transporter Neighboring gene D-mannonate oxidoreductase Neighboring gene DNA-binding transcriptional repressor UxuR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. Qiu X, et al. J Struct Biol, 2012 Nov. PMID 22796868
    2. Colonization ability and pathogenic properties of a fim- mutant of an avian strain of Escherichia coli. Marc D, et al. Res Microbiol, 1998 Jul-Aug. PMID 9766199
    3. [Purification and properties of D-mannonate hydrolyase from Escherichia coli K12]. Robert-Baudouy JM, et al. Biochim Biophys Acta, 1973 Jun 6. PMID 4581499
    4. [Genetic mapping and biochemical characterization of mutations in the mannonic hydrolyase structural gene of Escherichia coli K 12]. Robert-Baudouy JM, et al. Mol Gen Genet, 1972. PMID 4570161
    5. Uronic acid metabolism in bacteria. III. Purification and properties of D-altronic acid and D-mannonic acid dehydrases in Escherichia coli. SMILEY JD, et al. J Biol Chem, 1960 Jun. PMID 13831814

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannonate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucuronate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucuronate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-mannonate dehydratase
    NP_418742.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4551636..4552820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418742.1 D-mannonate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418742.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5GXW8, A0A5B9AQA4
      Conserved Domains (1) summary
      TIGR00695
      Location:1 → 394
      uxuA; mannonate dehydratase
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases