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    rlmF 23S rRNA m(6)A1618 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944938, updated on 25-Apr-2024

    Summary

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    Gene symbol
    rlmF
    Gene description
    23S rRNA m(6)A1618 methyltransferase
    Primary source
    ASAP:ABE-0002757
    Locus tag
    b0807
    See related
    ECOCYC:G6416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0796; ybiN
    Summary
    YbiN is rlmF; rlmF- has a slow growth phenotype (Sergiev, 2008). [More information is available at EcoGene: EG13319]. RlmF is the methyltransferase responsible for methylation of 23S rRNA at the N6 position of the A1618 nucleotide . [More information is available at EcoCyc: G6416].
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    Genomic context

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    Sequence:
    NC_000913.3 (842332..843258)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene iron catecholate outer membrane transporter Fiu Neighboring gene DUF1471 domain-containing protein McbA Neighboring gene moderate conductance mechanosensitive channel YbiO Neighboring gene L-glutamine ABC transporter ATP binding subunit Neighboring gene L-glutamine ABC transporter membrane subunit Neighboring gene L-glutamine ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. Sergiev PV, et al. J Mol Biol, 2008 Jan 4. PMID 18021804
    2. RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. Bujnicki JM, et al. BMC Bioinformatics, 2002 Apr 3. PMID 11929612, Free PMC Article
    3. Comparative genomics and evolution of proteins involved in RNA metabolism. Anantharaman V, et al. Nucleic Acids Res, 2002 Apr 1. PMID 11917006, Free PMC Article
    4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic cyclic compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA base methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    23S rRNA m(6)A1618 methyltransferase
    NP_415328.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      842332..843258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415328.4 23S rRNA m(6)A1618 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415328.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377AXW9, A0A776LR18
      Conserved Domains (1) summary
      PRK11727
      Location:1 → 308
      PRK11727; 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF
    Nucleotide Protein
    Heading Accession and Version

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