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    liuA isovaleryl-CoA dehydrogenase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879167, updated on 24-Sep-2023

    Summary

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    Gene symbol
    liuA
    Gene description
    isovaleryl-CoA dehydrogenase
    Locus tag
    PA2015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2205190..2206353, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene methylcrotonyl-CoA carboxylase subunit alpha Neighboring gene gamma-carboxygeranoyl-CoA hydratase Neighboring gene methylcrotonyl-CoA carboxylase subunit beta Neighboring gene liu genes regulator Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization of isovaleryl-CoA dehydrogenase (LiuA) of Pseudomonas aeruginosa and the importance of liu genes fora functional catabolic pathway of methyl-branched compounds. Förster-Fromme K, et al. FEMS Microbiol Lett, 2008 Sep. PMID 18625020
    2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
    5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LiuA prefers isovaleryl-CoA and butyryl-CoA as substrates.
      Title: Biochemical characterization of isovaleryl-CoA dehydrogenase (LiuA) of Pseudomonas aeruginosa and the importance of liu genes fora functional catabolic pathway of methyl-branched compounds.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables isovaleryl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isovaleryl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within isoprenoid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isovaleryl-CoA dehydrogenase
    NP_250705.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2205190..2206353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250705.1 isovaleryl-CoA dehydrogenase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250705.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I296
      Conserved Domains (1) summary
      cd01156
      Location:9 → 384
      IVD; Isovaleryl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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