U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MET16 phosphoadenylyl-sulfate reductase (thioredoxin) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856296, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MET16
    Official Full Name
    phosphoadenylyl-sulfate reductase (thioredoxin)
    Primary source
    SGD:S000006371
    Locus tag
    YPR167C
    See related
    AllianceGenome:SGD:S000006371; FungiDB:YPR167C; VEuPathDB:YPR167C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoadenylyl-sulfate reductase (thioredoxin) activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin). Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (876847..877632, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rho family GTPase RHO1 Neighboring gene mitochondrial 37S ribosomal protein MRP2 Neighboring gene mediator complex subunit NUT2 Neighboring gene Jip5p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate. Yu Z, et al. Biochemistry, 2008 Dec 2. PMID 18991405
    2. Histone acetylation, chromatin remodelling, transcription and nucleotide excision repair in S. cerevisiae: studies with two model genes. Teng Y, et al. DNA Repair (Amst), 2005 Jul 28. PMID 15950549
    3. Yeast PAPS reductase: properties and requirements of the purified enzyme. Schwenn JD, et al. Arch Microbiol, 1988. PMID 3060034
    4. Inhibition of 5' to 3' mRNA degradation under stress conditions in Saccharomyces cerevisiae: from GCN4 to MET16. Benard L. RNA, 2004 Mar. PMID 14970391, Free PMC Article
    5. Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity. Gutierrez-Marcos JF, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917599, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ada2p and Gcn5p regulates transcription and DNA repair at the MET16 gene.
      Title: Roles for Gcn5p and Ada2p in transcription and nucleotide excision repair at the Saccharomyces cerevisiae MET16 gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphoadenylyl-sulfate reductase (thioredoxin)
    NP_015493.1
    • 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      876847..877632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184264.1 → NP_015493.1  TPA: phosphoadenylyl-sulfate reductase (thioredoxin) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4G8, P18408, Q06212
      UniProtKB/TrEMBL
      A6ZX43, B3LKC8, B5VTV1, C7GP50, C8ZJJ3, G2WPY0, N1NXV3
      Conserved Domains (1) summary
      TIGR02057
      Location:17 → 248
      PAPS_reductase; phosphoadenosine phosphosulfate reductase, thioredoxin dependent
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18408.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools