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    ALG5 dolichyl-phosphate beta-glucosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855874, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALG5
    Official Full Name
    dolichyl-phosphate beta-glucosyltransferase
    Primary source
    SGD:S000006148
    Locus tag
    YPL227C
    See related
    AllianceGenome:SGD:S000006148; FungiDB:YPL227C; VEuPathDB:YPL227C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dolichyl-phosphate beta-glucosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (120163..121167, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene polynucleotide 5'-phosphatase Neighboring gene New1p Neighboring gene ribosome-associated Tef1p biogenesis chaperone CHP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiae. Heesen S, et al. Eur J Biochem, 1994 Aug 15. PMID 8076653
    2. Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway. Runge KW, et al. J Biol Chem, 1984 Jan 10. PMID 6423630
    3. Evidence that the synthesis of glucosylphosphodolichol in yeast involves a 35-kDa membrane protein. Palamarczyk G, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 2138781, Free PMC Article
    4. A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. Stagljar I, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560251, Free PMC Article
    5. A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Mendelsohn RD, et al. Biochim Biophys Acta, 2005 May 25. PMID 15794922

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dolichyl-phosphate beta-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-phosphate beta-glucosyltransferase
    NP_015097.1
    • UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      120163..121167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184041.1 → NP_015097.1  TPA: dolichyl-phosphate beta-glucosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E3, P40350
      UniProtKB/TrEMBL
      C7GU66, G2WNV8, N1P2K3
      Conserved Domains (1) summary
      cd04188
      Location:77 → 302
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40350.1

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