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    IPT1 isopentenyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843175, updated on 7-Sep-2023

    Summary

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    Gene symbol
    IPT1
    Gene description
    isopentenyltransferase 1
    Primary source
    Araport:AT1G68460
    Locus tag
    AT1G68460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana isopentenyltransferase 1; ATIPT1; ATP/ADP ISOPENTENYLTRANSFERASE; isopentenyltransferase 1; T26J14.3; T26J14_3
    Summary
    Encodes a putative adenylate isopentenyltransferase. It catalyzes the formation of isopentenyladenosine 5'-monophosphate (iPMP) from AMP and dimethylallylpyrophosphate (DMAPP), but it has a lower Km for ADP and likely works using ADP or ATP in plants. It is involved in cytokinin biosynthesis.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (25668610..25670345, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene VQ motif-containing protein Neighboring gene Exostosin family protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytokinins are central regulators of cambial activity. Matsumoto-Kitano M, et al. Proc Natl Acad Sci U S A, 2008 Dec 16. PMID 19074290, Free PMC Article
    2. Effects of conditional IPT-dependent cytokinin overproduction on root architecture of Arabidopsis seedlings. Kuderová A, et al. Plant Cell Physiol, 2008 Apr. PMID 18296451
    3. Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases. Kakimoto T. Plant Cell Physiol, 2001 Jul. PMID 11479373
    4. Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana. Takei K, et al. J Biol Chem, 2001 Jul 13. PMID 11313355
    5. Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant. Sakakibara H, et al. Proc Natl Acad Sci U S A, 2005 Jul 12. PMID 15998742, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_105517.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP dimethylallyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP dimethylallyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP dimethylallyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ATP dimethylallyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isopentenyltransferase 1
    NP_177013.1
    • isopentenyltransferase 1 (IPT1); FUNCTIONS IN: AMP dimethylallyltransferase activity, ATP/ADP dimethylallyltransferase activity; INVOLVED IN: cytokinin biosynthetic process, secondary growth; LOCATED IN: chloroplast; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: tRNA isopentenyltransferase (InterPro:IPR002627); BEST Arabidopsis thaliana protein match is: ATP/ADP isopentenyltransferases (TAIR:AT3G19160.1); Has 7944 Blast hits to 7761 proteins in 2606 species: Archae - 0; Bacteria - 5388; Metazoa - 167; Fungi - 152; Plants - 293; Viruses - 0; Other Eukaryotes - 1944 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25668610..25670345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105517.2 → NP_177013.1  isopentenyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94ID3, Q9CA35
      UniProtKB/TrEMBL
      A0A178W6I2, A0A5S9WTM9, A0A654EM67
      Conserved Domains (1) summary
      PLN02165
      Location:41 → 357
      PLN02165; adenylate isopentenyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94ID3.2

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