PEX6 peroxin 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: PEX6
Gene description: peroxin 6
Primary source: Araport:AT1G03000
Locus tag: AT1G03000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F10O3.18; F10O3_18; peroxin 6
Summary: Encodes an apparent ATPase similar to yeast and human protein required for peroxisomal biogenesis. May facilitate recycling of PEX5, the peroxisomal matrix protein receptor, and thereby promote peroxisomal matrix protein import.
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Genomic context

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Location:: chromosome: 1

Exon count:: 13

Sequence:: Chromosome: 1; NC_003070.9 (687795..692660, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beyond PEX5 recycling, PEX1 and PEX6 have additional functions in peroxisome homeostasis and perhaps in oil body utilization
Title: A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling.
These results illuminate roles for PEX6 and PEX26 in the import and export of peroxisomal proteins and reveal possible functions in oil body utilization.
Title: Disparate peroxisome-related defects in Arabidopsis pex6 and pex26 mutants link peroxisomal retrotranslocation and oil body utilization.
genetic, molecular, and physiological data support the heterohexamer model of PEX1-PEX6 function in plants.
Title: The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.
PEX1 and PEX6 comprise a heterooligomer and this complex was recruited to peroxisomal membranes via protein-protein interactions of APEM9 with PEX6.
Title: Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes.
pex6 mutants display general peroxisome-defective phenotypes, including sucrose dependence during germination, resistance to the auxin precursor indole-3-butyric acid, and photorespiration defects.
Title: An Arabidopsis indole-3-butyric acid-response mutant defective in PEROXIN6, an apparent ATPase implicated in peroxisomal function.
Pex6 mutants are impaired in wound-induced formation of jasmonic acid.
Title: Jasmonate biosynthesis in Arabidopsis thaliana requires peroxisomal beta-oxidation enzymes--additional proof by properties of pex6 and aim1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100181.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: peroxin 6

NP_171799.2

peroxin 6 (PEX6); FUNCTIONS IN: nucleoside-triphosphatase activity, ATPase activity, nucleotide binding, ATP binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, conserved site (InterPro:IPR003960); BEST Arabidopsis thaliana protein match is: ATPase, AAA-type, CDC48 protein (TAIR:AT5G03340.1); Has 36036 Blast hits to 31766 proteins in 3165 species: Archae - 1626; Bacteria - 13920; Metazoa - 5344; Fungi - 4031; Plants - 3389; Viruses - 33; Other Eukaryotes - 7693 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

687795..692660 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100181.5 → NP_171799.2 peroxin 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171799.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RY16, Q9SA70

UniProtKB/TrEMBL

A0A178WG59, A0A5S9SC27, A0A7G2DS20

Conserved Domains (2) summary

TIGR01243
Location:380 → 937

CDC48; AAA family ATPase, CDC48 subfamily

cd19527
Location:666 → 825

RecA-like_PEX6_r2; second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6)