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    RMI1 recQ-mediated instability protein (DUF1767) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836473, updated on 7-Sep-2023

    Summary

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    Gene symbol
    RMI1
    Gene description
    recQ-mediated instability protein (DUF1767)
    Primary source
    Araport:AT5G63540
    Locus tag
    AT5G63540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRMI1; BLAP75; MLE2.17; MLE2_17; RECQ MEDIATED INSTABILITY 1
    Summary
    Encodes RMI1. Suppresses somatic crossovers. Essential for resolution of meiotic recombination intermediates.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (25440783..25444471, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene farnesylated protein 3 Neighboring gene ncRNA Neighboring gene DEK domain-containing chromatin associated protein Neighboring gene HXXXD-type acyl-transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination. Chen P, et al. EMBO J, 2023 May 15. PMID 36970874, Free PMC Article
    2. Different functions for the domains of the Arabidopsis thaliana RMI1 protein in DNA cross-link repair, somatic and meiotic recombination. Bonnet S, et al. Nucleic Acids Res, 2013 Nov. PMID 23956219, Free PMC Article
    3. The Arabidopsis BLAP75/Rmi1 homologue plays crucial roles in meiotic double-strand break repair. Chelysheva L, et al. PLoS Genet, 2008 Dec. PMID 19096505, Free PMC Article
    4. Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. Hartung F, et al. PLoS Genet, 2008 Dec. PMID 19096507, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.
      Title: KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.
    2. The results show that the DUF1767 domain and the OB-fold domain 1 are both essential for the function of AtRMI1 in DNA cross-link repair as well as meiotic recombination, but partially dispensable for somatic homologous recombination suppression.
      Title: Different functions for the domains of the Arabidopsis thaliana RMI1 protein in DNA cross-link repair, somatic and meiotic recombination.
    3. AtTOP3alpha and AtRMI1 are involved in the suppression of crossover recombination in somatic cells and DNA repair.
      Title: Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.
    4. BLAP75/Rmi1 is a key protein of the meiotic homologous recombination machinery.
      Title: The Arabidopsis BLAP75/Rmi1 homologue plays crucial roles in meiotic double-strand break repair.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001126014.1
    NM_125749.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    recQ-mediated instability protein (DUF1767)
    NP_001119486.1
    • RECQ MEDIATED INSTABILITY 1 (RMI1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: meiosis, double-strand break repair via homologous recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: shoot apex, inflorescence meristem, sperm cell, flower, seed; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1767 (InterPro:IPR013894); BEST Arabidopsis thaliana protein match is: Domain of unknown function (DUF1767) (TAIR:AT5G19950.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_201159.2
    • RECQ MEDIATED INSTABILITY 1 (RMI1); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1767 (InterPro:IPR013894); BEST Arabidopsis thaliana protein match is: Domain of unknown function (DUF1767) (TAIR:AT5G19950.3); Has 297 Blast hits to 286 proteins in 91 species: Archae - 0; Bacteria - 10; Metazoa - 136; Fungi - 20; Plants - 89; Viruses - 0; Other Eukaryotes - 42 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25440783..25444471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125749.5 → NP_201159.2  recQ-mediated instability protein (DUF1767) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201159.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5XUX6, Q9FMU8
      UniProtKB/TrEMBL
      A0A5S9YGM8
      Conserved Domains (3) summary
      pfam08585
      Location:104 → 271
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:483 → 622
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold
      cl19731
      Location:288 → 466
      SipA; Salmonella invasion protein A

    2. NM_001126014.1 → NP_001119486.1  recQ-mediated instability protein (DUF1767) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UG87, A0A654GDN1, A0A7G2FII9, B3H7H7
      Conserved Domains (3) summary
      pfam08585
      Location:104 → 271
      RMI1_N; RecQ mediated genome instability protein
      pfam16099
      Location:516 → 655
      RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold
      cl19731
      Location:321 → 499
      SipA; Salmonella invasion protein A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XUX6.1

    Gene LinkOut

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