EFR EF-TU receptor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: EFR
Gene description: EF-TU receptor
Primary source: Araport:AT5G20480
Locus tag: AT5G20480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EF-TU receptor; F7C8.70; F7C8_70
Summary: Encodes a predicted leucine-rich repeat receptor kinase (LRR-RLK). Functions as the receptor for bacterial PAMP (pathogen associated molecular patterns) EF-Tu.
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Genomic context

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Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (6921509..6925901)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation loop phosphorylaton of a non-RD receptor kinase initiates plant innate immune signaling.
Title: Activation loop phosphorylation of a non-RD receptor kinase initiates plant innate immune signaling.
expression in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis
Title: Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis.
These findings demonstrate the mechanistic basis of signal transduction from EFR to phytohormones, mediated through a EFR-BIK1-WRKY axis.
Title: The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity.
transgenic rice plants (Oryza sativa L. ssp. japonica cv. Zhonghua 17) and cell cultures with constitutive expression of AtEFR were developed to investigate whether AtEFR senses EF-Tu and thus enhances bacterial resistance in the monocot plants.
Title: Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR.
When challenged with the cereal bacterial pathogen Pseudomonas syringae pv. oryzae, transgenic EFR wheat lines had reduced lesion size and bacterial multiplication.
Title: Arabidopsis EF-Tu receptor enhances bacterial disease resistance in transgenic wheat.
study first mapped the phosphorylation patterns of BAK1 associated with four RLK partners (BRI1, FLS2, EFR and BIK1
Title: Assessment of BAK1 activity in different plant receptor-like kinase complexes by quantitative profiling of phosphorylation patterns.
OST3/6 deficiency affects the biogenesis of EFR, resulting in the impairment of innate immunity. OST3/6 plays an important role for abiotic stress tolerance and for the functionality of the endoglucanase KOR1 essential for cellulose biosynthesis.
Title: Specialized roles of the conserved subunit OST3/6 of the oligosaccharyltransferase complex in innate immunity and tolerance to abiotic stresses.
A knockout mutant showed reduced downy mildew infection, but susceptibility was fully restored through complementation of the mutation, suggesting that the (malectin like)LRR-RLK contributes to disease.
Title: An Arabidopsis (malectin-like) leucine-rich repeat receptor-like kinase contributes to downy mildew disease.
The effects of protein domain mutations on the binding properties of EFR and FLS2 are reported.
Title: Chimeric receptors of the Arabidopsis thaliana pattern recognition receptors EFR and FLS2.
The ligand-induced heteromerization of EFR and FLS2 with BAK1 is independent of kinase activity in planta.
Title: Phosphorylation-dependent differential regulation of plant growth, cell death, and innate immunity by the regulatory receptor-like kinase BAK1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001343669.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune response-regulating signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pathogen-associated molecular pattern receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: EF-TU receptor

NP_001318610.1

EF-TU receptor (EFR); FUNCTIONS IN: protein serine/threonine kinase activity, transmembrane receptor protein kinase activity, kinase activity, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT3G47090.1); Has 211073 Blast hits to 132033 proteins in 4602 species: Archae - 167; Bacteria - 19808; Metazoa - 69159; Fungi - 9873; Plants - 87247; Viruses - 333; Other Eukaryotes - 24486 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

6921509..6925901

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122055.5 → NP_197548.1 EF-TU receptor [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197548.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0LGT6, Q0WWU8, Q8S9I3

UniProtKB/TrEMBL

A0A5S9Y5X1

Conserved Domains (5) summary

PLN00113
Location:20 → 1006

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00116
Location:394 → 597

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:346 → 370

LRR_RI; leucine-rich repeat [structural motif]

pfam08263
Location:28 → 68

LRRNT_2; Leucine rich repeat N-terminal domain

cl21453
Location:718 → 996

PKc_like; Protein Kinases, catalytic domain
NM_001343669.1 → NP_001318610.1 EF-TU receptor [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C0LGT6, Q0WWU8, Q8S9I3

UniProtKB/TrEMBL

A0A5S9Y5X1