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    TDP1 tyrosyl-DNA phosphodiesterase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831369, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TDP1
    Official Full Name
    tyrosyl-DNA phosphodiesterase-like protein
    Primary source
    TAIR:AT5G15170
    Locus tag
    AT5G15170
    See related
    Araport:AT5G15170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F8M21.60; F8M21_60; tyrosyl-DNA phosphodiesterase 1
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (4925850..4929502, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BANQUO 2 Neighboring gene tRNA-Val Neighboring gene Peroxidase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis. Lee SY, et al. Plant Physiol, 2010 Nov. PMID 20876339, Free PMC Article
    2. Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana. Kim H, et al. Biochem J, 2012 Apr 1. PMID 22214184, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the results of the present study demonstrate the structure-based function of AtTDP through which AtTDP can repair DNA strand breaks in plants
      Title: Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana.
    2. AtTDP plays a clear role in the repair of topoisomerase I-DNA complexes.
      Title: Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121521.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-tyrosyl-DNA phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosyl-DNA phosphodiesterase-like protein
    NP_197021.2
    • tyrosyl-DNA phosphodiesterase-related; FUNCTIONS IN: 3'-tyrosyl-DNA phosphodiesterase activity; INVOLVED IN: DNA repair; LOCATED IN: nucleus; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Tyrosyl-DNA phosphodiesterase (InterPro:IPR010347), SMAD/FHA domain (InterPro:IPR008984); BEST Arabidopsis thaliana protein match is: forkhead-associated domain-containing protein / FHA domain-containing protein (TAIR:AT5G07400.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4925850..4929502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121521.4 → NP_197021.2  tyrosyl-DNA phosphodiesterase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197021.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1D9, Q8VZM6, Q9LXG4
      UniProtKB/TrEMBL
      A0A178UHD6, A0A5S9Y4Z1
      Conserved Domains (1) summary
      pfam06087
      Location:144 → 577
      Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1D9.1

    Gene LinkOut

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