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    AK3 aspartate kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821287, updated on 15-Oct-2023

    Summary

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    Gene symbol
    AK3
    Gene description
    aspartate kinase 3
    Primary source
    Araport:AT3G02020
    Locus tag
    AT3G02020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aspartate kinase 3; F1C9.20; F1C9_20
    Summary
    encodes a monofunctional aspartate kinase
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (337712..343912, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ACT domain repeat 6 Neighboring gene Thioredoxin superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene transferase Neighboring gene senescence-related gene 3 Neighboring gene K+ uptake transporter 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a monofunctional aspartate kinase gene of Arabidopsis thaliana with spatially and temporally regulated expression. Yoshioka Y, et al. Genes Genet Syst, 2001 Jun. PMID 11569502
    2. Cloning and expression of an Arabidopsis thaliana cDNA encoding a monofunctional aspartate kinase homologous to the lysine-sensitive enzyme of Escherichia coli. Tang G, et al. Plant Mol Biol, 1997 May. PMID 9207844
    3. Allosteric monofunctional aspartate kinases from Arabidopsis. Curien G, et al. FEBS J, 2007 Jan. PMID 17140415
    4. Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents. Clark TJ, et al. Plant Physiol, 2015 Aug. PMID 26063505, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_111068.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aspartate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aspartate family amino acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    aspartate kinase 3
    NP_186851.1
    • aspartate kinase 3 (AK3); CONTAINS InterPro DOMAIN/s: Aspartate kinase, conserved site (InterPro:IPR018042), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Amino acid-binding ACT (InterPro:IPR002912), Aspartate kinase domain (InterPro:IPR001341); BEST Arabidopsis thaliana protein match is: Aspartate kinase family protein (TAIR:AT5G14060.2); Has 11044 Blast hits to 11020 proteins in 2545 species: Archae - 256; Bacteria - 7570; Metazoa - 4; Fungi - 149; Plants - 183; Viruses - 0; Other Eukaryotes - 2882 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      337712..343912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111068.4 → NP_186851.1  aspartate kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S702
      UniProtKB/TrEMBL
      A0A5S9X8E7, A0A654FDS8
      Conserved Domains (1) summary
      PLN02551
      Location:32 → 552
      PLN02551; aspartokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S702.1

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