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    FAD7 fatty acid desaturase 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820288, updated on 7-Sep-2023

    Summary

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    Gene symbol
    FAD7
    Gene description
    fatty acid desaturase 7
    Primary source
    Araport:AT3G11170
    Locus tag
    AT3G11170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtFAD7; CHLOROPLAST PRECURSOR; FADD; fatty acid desaturase 7; FATTY ACID DESATURASE D; OMEGA-3 FATTY ACID DESATURASE
    Summary
    Chloroplastic enzyme responsible for the synthesis of 16:3 and 18:3 fatty acids from galactolipids, sulpholipids and phosphatidylglycerol. Uses ferredoxin as electron donor. Gene expression is induced by wounding in shoot and root. The wound-response in shoot is independent of jasmonic acid mediated pathway whereas the root response is mediated by jasmonic acid.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (3499537..3502452)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene alfin-like 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ozone-induced expression of the Arabidopsis FAD7 gene requires salicylic acid, but not NPR1 and SID2. Yaeno T, et al. Plant Cell Physiol, 2006 Mar. PMID 16415067
    2. Enhanced cold tolerance in transgenic tobacco expressing a chloroplast omega-3 fatty acid desaturase gene under the control of a cold-inducible promoter. Khodakovskaya M, et al. Planta, 2006 Apr. PMID 16292565
    3. Genetic Enhancement of Cold Tolerance by Expression of a Gene for Chloroplast [omega]-3 Fatty Acid Desaturase in Transgenic Tobacco. Kodama H, et al. Plant Physiol, 1994 Jun. PMID 12232227, Free PMC Article
    4. Wounding changes the spatial expression pattern of the arabidopsis plastid omega-3 fatty acid desaturase gene (FAD7) through different signal transduction pathways. Nishiuchi T, et al. Plant Cell, 1997 Oct. PMID 9368411, Free PMC Article
    5. A gene encoding a chloroplast omega-3 fatty acid desaturase complements alterations in fatty acid desaturation and chloroplast copy number of the fad7 mutant of Arabidopsis thaliana. Iba K, et al. J Biol Chem, 1993 Nov 15. PMID 8226956

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the codon preference of FAD7 is influenced by genetic relationships
      Title: Analysis of synonymous codon usage in FAD7 genes from different plant species.
    2. FAD7 catalyses the production of jasmonic acid, andis induced locally by wounding. RNA polymerase II C-terminal domain phosphatases are negative regulators of FAD7 expression.
      Title: CTD phosphatases in the attenuation of wound-induced transcription of jasmonic acid biosynthetic genes in Arabidopsis.
    3. When young, cold-induced tobacco seedlings were exposed to low-temperature (0.5, 2 or 3.5 degrees C) for up to 44 days, survival within independent cor15a-FAD7 transgenic lines (40.2-96%) was far superior to the wild type (6.7-10.2%).
      Title: Enhanced cold tolerance in transgenic tobacco expressing a chloroplast omega-3 fatty acid desaturase gene under the control of a cold-inducible promoter.
    4. These results suggest that the ozone-induced expression of FAD7 gene requires SA, but not ethylene, JA, NPR1 and SID2.
      Title: Ozone-induced expression of the Arabidopsis FAD7 gene requires salicylic acid, but not NPR1 and SID2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111953.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega-3 fatty acid desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid desaturase 7
    NP_187727.1
    • fatty acid desaturase 7 (FAD7); FUNCTIONS IN: omega-3 fatty acid desaturase activity; INVOLVED IN: response to cold, response to wounding, fatty acid biosynthetic process, jasmonic acid mediated signaling pathway; LOCATED IN: plastid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3474 (InterPro:IPR021863), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: fatty acid desaturase 8 (TAIR:AT5G05580.1); Has 2938 Blast hits to 2935 proteins in 698 species: Archae - 0; Bacteria - 1234; Metazoa - 17; Fungi - 265; Plants - 926; Viruses - 0; Other Eukaryotes - 496 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3499537..3502452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111953.3 → NP_187727.1  fatty acid desaturase 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46310
      UniProtKB/TrEMBL
      A0A178VH06, A0A654F5Z9, Q94EW6
      Conserved Domains (1) summary
      PLN02498
      Location:1 → 442
      PLN02498; omega-3 fatty acid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46310.1

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