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    METTL25B methyltransferase like 25B [ Homo sapiens (human) ]

    Gene ID: 51093, updated on 3-Apr-2024

    Summary

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    Official Symbol
    METTL25Bprovided by HGNC
    Official Full Name
    methyltransferase like 25Bprovided by HGNC
    Primary source
    HGNC:HGNC:24273
    See related
    Ensembl:ENSG00000143303 AllianceGenome:HGNC:24273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-41; RRNAD1; C1orf66
    Summary
    Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.0), prostate (RPKM 8.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156728469..156736960)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155864872..155873793)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156698261..156706752)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156642834-156643494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156643495-156644156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156645479-156646139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156646801-156647461 Neighboring gene nestin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156661895-156662812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. Peterson RJ, et al. J Periodontol, 1979 Jan. PMID 310876
    2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Chapuis J, et al. Mol Psychiatry, 2009 Nov. PMID 19204726, Free PMC Article
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
    4. Discovery and refinement of loci associated with lipid levels. Willer CJ, et al. Nat Genet, 2013 Nov. PMID 24097068, Free PMC Article
    5. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain R, et al. Cell Host Microbe, 2019 Jul 10. PMID 31253590, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase-like protein 25B
    Names
    protein RRNAD1
    ribosomal RNA adenine dimethylase domain containing 1
    ribosomal RNA adenine dimethylase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142560.2 → NP_001136032.1  methyltransferase-like protein 25B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590666, BX094595
      Consensus CDS
      CCDS44246.1
      UniProtKB/Swiss-Prot
      Q96FB5
      Related
      ENSP00000357201.4, ENST00000368218.8
      Conserved Domains (1) summary
      cl17173
      Location:133 → 221
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_015997.4 → NP_057081.3  methyltransferase-like protein 25B isoform 1

      See identical proteins and their annotated locations for NP_057081.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL590666, BX094595
      Consensus CDS
      CCDS1154.1
      UniProtKB/Swiss-Prot
      D3DVC7, Q4VX71, Q5SZ03, Q96FB5, Q9Y358
      Related
      ENSP00000357199.4, ENST00000368216.9
      Conserved Domains (1) summary
      pfam13679
      Location:133 → 293
      Methyltransf_32; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156728469..156736960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245234.6 → XP_005245291.1  methyltransferase-like protein 25B isoform X1

      Conserved Domains (1) summary
      pfam13679
      Location:133 → 293
      Methyltransf_32; Methyltransferase domain

    2. XM_024447421.2 → XP_024303189.1  methyltransferase-like protein 25B isoform X9

      Conserved Domains (1) summary
      cl17173
      Location:133 → 224
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_005245236.6 → XP_005245293.1  methyltransferase-like protein 25B isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:133 → 222
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_005245237.6 → XP_005245294.1  methyltransferase-like protein 25B isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:133 → 221
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_005245235.6 → XP_005245292.1  methyltransferase-like protein 25B isoform X3

      Conserved Domains (1) summary
      pfam13679
      Location:63 → 223
      Methyltransf_32; Methyltransferase domain

    6. XM_047421948.1 → XP_047277904.1  methyltransferase-like protein 25B isoform X10

    7. XM_011509600.2 → XP_011507902.1  methyltransferase-like protein 25B isoform X2

      Conserved Domains (1) summary
      pfam13679
      Location:67 → 227
      Methyltransf_32; Methyltransferase domain

    8. XM_047421932.1 → XP_047277888.1  methyltransferase-like protein 25B isoform X4

      Related
      ENSP00000429756.1, ENST00000519086.5

    9. XM_047421937.1 → XP_047277893.1  methyltransferase-like protein 25B isoform X5

    10. XM_047421943.1 → XP_047277899.1  methyltransferase-like protein 25B isoform X8

    11. XM_047421944.1 → XP_047277900.1  methyltransferase-like protein 25B isoform X8

    12. XM_017001404.2 → XP_016856893.1  methyltransferase-like protein 25B isoform X2

      Conserved Domains (1) summary
      pfam13679
      Location:67 → 227
      Methyltransf_32; Methyltransferase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155864872..155873793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336874.1 → XP_054192849.1  methyltransferase-like protein 25B isoform X6

    2. XM_054336871.1 → XP_054192846.1  methyltransferase-like protein 25B isoform X3

    3. XM_054336879.1 → XP_054192854.1  methyltransferase-like protein 25B isoform X10

    4. XM_054336869.1 → XP_054192844.1  methyltransferase-like protein 25B isoform X1

    5. XM_054336878.1 → XP_054192853.1  methyltransferase-like protein 25B isoform X9

    6. XM_054336875.1 → XP_054192850.1  methyltransferase-like protein 25B isoform X7

    7. XM_054336872.1 → XP_054192847.1  methyltransferase-like protein 25B isoform X4

    8. XM_054336876.1 → XP_054192851.1  methyltransferase-like protein 25B isoform X8

    9. XM_054336877.1 → XP_054192852.1  methyltransferase-like protein 25B isoform X8

    10. XM_054336870.1 → XP_054192845.1  methyltransferase-like protein 25B isoform X2

    11. XM_054336873.1 → XP_054192848.1  methyltransferase-like protein 25B isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FB5.2 GenPept UniProtKB/Swiss-Prot:Q96FB5

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