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    Rtf1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37554, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Rtf1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034722
    Locus tag
    Dmel_CG10955
    See related
    AllianceGenome:FB:FBgn0034722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10955; Dmel\CG10955; dRtf1; rtf1
    Summary
    Predicted to enable DNA binding activity. Involved in positive regulation of histone H3-K4 trimethylation and positive regulation of transcription by RNA polymerase II. Located in nucleus and transcriptionally active chromatin. Is expressed in spermatid and spermatocyte. Orthologous to human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    58D4-58D4; 2-99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22375090..22378484)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18262595..18265989)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Liprin-gamma Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44759 Neighboring gene long non-coding RNA:CR45327 Neighboring gene wrapper Neighboring gene long non-coding RNA:CR44757 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity. Clark JP, et al. Curr Biol, 2017 Sep 11. PMID 28844648, Free PMC Article
    2. Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Adelman K, et al. Mol Cell Biol, 2006 Jan. PMID 16354696, Free PMC Article
    3. Reversible perturbations of gene regulation after genome editing in Drosophila cells. Kunzelmann S, et al. PLoS One, 2017. PMID 28658280, Free PMC Article
    4. Role of the Paf1 complex in the maintenance of stem cell pluripotency and development. Park J, et al. FEBS J, 2023 Feb. PMID 35869661
    5. Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells. Deng Q, et al. PLoS Biol, 2022 Oct. PMID 36223339, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the dRtf1 component of the Paf1 complex functions in Notch signaling
      Title: Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rtf1
    Names
    CG10955-PA
    CG10955-PB
    Rtf1-PA
    Rtf1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22375090..22378484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299788.1 → NP_001286717.1  Rtf1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W261
      UniProtKB/TrEMBL
      A9UNB4, H0RNK7
      Conserved Domains (1) summary
      smart00719
      Location:428 → 535
      Plus3; Short conserved domain in transcriptional regulators

    2. NM_137821.3 → NP_611665.1  Rtf1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W261
      UniProtKB/TrEMBL
      A9UNB4, H0RNK7
      Related
      FBpp0071731
      Conserved Domains (1) summary
      smart00719
      Location:428 → 535
      Plus3; Short conserved domain in transcriptional regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H0RNK7 H0RNK7
    Q9W261.1 Q9W261

    Gene LinkOut

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