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    CG10958 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31736, updated on 26-Apr-2024

    Summary

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    Official Symbol
    CG10958provided by FlyBase
    Primary source
    FLYBASE:FBgn0030004
    Locus tag
    Dmel_CG10958
    See related
    AllianceGenome:FB:FBgn0030004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10958
    Summary
    Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in chordotonal neurons; embryonic head sensory system; male germline cell; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    7D12-7D13; 1-22 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8132285..8134967)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8026318..8029000)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cypher Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Smad on X Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    2. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10958-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8132285..8134967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132217.4 → NP_572445.1  uncharacterized protein Dmel_CG10958 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W3J8
      Related
      FBpp0071104
      Conserved Domains (2) summary
      pfam14772
      Location:120 → 220
      NYD-SP28; Sperm tail
      pfam14775
      Location:684 → 741
      NYD-SP28_assoc; Sperm tail C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3J8.1 Q9W3J8

    Gene LinkOut

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