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    US16 membrane protein US16 [ Human betaherpesvirus 5 ]

    Gene ID: 3077558, updated on 18-Aug-2023

    Summary

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    Gene symbol
    US16
    Gene description
    membrane protein US16
    Locus tag
    HHV5wtgp147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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    Genomic context

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    Sequence:
    NC_006273.2 (210366..211295, complement)

    NC_006273.2Genomic Context describing neighboring genes Neighboring gene membrane protein US14 Neighboring gene membrane protein US15 Neighboring gene membrane protein US17 Neighboring gene membrane protein US18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006273.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the Human Cytomegalovirus US16 Protein Abrogates Virus Entry into Endothelial and Epithelial Cells by Reducing the Virion Content of the Pentamer. Luganini A, et al. J Virol, 2017 Jun 1. PMID 28331097, Free PMC Article
    2. The US16 gene of human cytomegalovirus is required for efficient viral infection of endothelial and epithelial cells. Bronzini M, et al. J Virol, 2012 Jun. PMID 22496217, Free PMC Article
    3. High-resolution human cytomegalovirus transcriptome. Gatherer D, et al. Proc Natl Acad Sci U S A, 2011 Dec 6. PMID 22109557, Free PMC Article
    4. Genetic content of wild-type human cytomegalovirus. Dolan A, et al. J Gen Virol, 2004 May. PMID 15105547
    5. The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro. McSharry BP, et al. J Gen Virol, 2003 Sep. PMID 12917473

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study suggests pUS16 as a novel viral regulatory protein important for shaping virion composition in a manner that influences HCMV cell tropism.
      Title: Loss of the Human Cytomegalovirus US16 Protein Abrogates Virus Entry into Endothelial and Epithelial Cells by Reducing the Virion Content of the Pentamer.
    2. US16 gene is required for efficient viral infection of endothelial and epithelial cells.
      Title: The US16 gene of human cytomegalovirus is required for efficient viral infection of endothelial and epithelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    membrane protein US16
    YP_081601.1
    • US12 family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006273.2 Reference assembly

      Range
      210366..211295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_081601.1 membrane protein US16 [Human betaherpesvirus 5]

      See identical proteins and their annotated locations for YP_081601.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      D2K3W1, Q6SVZ0
      UniProtKB/TrEMBL
      A0A0U3BM91, D2K5P9, F5HC84
    Nucleotide Protein
    Heading Accession and Version

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