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    mel-11 cGMP-dependent protein kinase interacting domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174484, updated on 5-May-2024

    Summary

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    Gene symbol
    mel-11
    Gene description
    cGMP-dependent protein kinase interacting domain-containing protein
    Primary source
    WormBase:WBGene00003196
    Locus tag
    CELE_C06C3.1
    See related
    AllianceGenome:WB:WBGene00003196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Involved in embryo development and embryonic body morphogenesis. Located in adherens junction and cytoplasm. Is expressed in several structures, including P1; P2; P3; P4; and hypodermal cell. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mel-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (9358530..9369099)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Coelomocyte uptake defective protein 15 Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein Neighboring gene Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway. Wissmann A, et al. Dev Biol, 1999 May 1. PMID 10208747
    2. The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine. Cox-Paulson E, et al. Dev Dyn, 2014 Jun. PMID 24677443, Free PMC Article
    3. pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans. Martin E, et al. PLoS One, 2014. PMID 24732978, Free PMC Article
    4. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Wissmann A, et al. Genes Dev, 1997 Feb 15. PMID 9042856
    5. Tissue-Specific Functions of fem-2/PP2c Phosphatase and fhod-1/formin During Caenorhabditis elegans Embryonic Morphogenesis. Refai O, et al. G3 (Bethesda), 2018 Jul 2. PMID 29720391, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans
      Title: pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.
    2. Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans.
      Title: The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-dependent protein kinase interacting domain-containing protein
    NP_001021928.1
    • Confirmed by transcript evidence
    NP_001379325.1
    • Confirmed by transcript evidence
    NP_001379421.1
    • Confirmed by transcript evidence
    NP_495994.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9358530..9369099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393153.1 → NP_001379325.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGT0
      Conserved Domains (5) summary
      PHA03095
      Location:60 → 280
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87 → 118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 151
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:906 → 1018
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21930
      Location:655 → 701
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    2. NM_001026757.4 → NP_001021928.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECD7
      Conserved Domains (4) summary
      PHA03095
      Location:60 → 280
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87 → 118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 151
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1011 → 1123
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    3. NM_001393154.1 → NP_001379421.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG29
      Conserved Domains (5) summary
      PHA03095
      Location:60 → 280
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87 → 118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 151
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:855 → 967
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21930
      Location:652 → 698
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    4. NM_063593.7 → NP_495994.1  cGMP-dependent protein kinase interacting domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEB3
      Conserved Domains (4) summary
      PHA03095
      Location:60 → 280
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:87 → 118
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 151
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:903 → 1015
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    Nucleotide Protein
    Heading Accession and Version

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