tyms-1 Thymidylate synthase [Caenorhabditis elegans] - Gene

Summary

Gene symbol: tyms-1
Gene description: Thymidylate synthase
Primary source: WormBase:WBGene00022455
Locus tag: CELE_Y110A7A.4
See related: AllianceGenome:WB:WBGene00022455
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables thymidylate synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring one-carbon groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dTMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_491532.3

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