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    Dynlt1c dynein light chain Tctex-type 1C [ Mus musculus (house mouse) ]

    Gene ID: 100040563, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Dynlt1cprovided by MGI
    Official Full Name
    dynein light chain Tctex-type 1Cprovided by MGI
    Primary source
    MGI:MGI:3807476
    See related
    Ensembl:ENSMUSG00000000579 AllianceGenome:MGI:3807476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AGS2; Dynlt1; Tctel1; Tctex1; Dynlt1d; Tctex-1; 100040603
    Summary
    Predicted to enable identical protein binding activity and protein C-terminus binding activity. Predicted to be involved in several processes, including intracellular transport of viral protein in host cell; neuron projection development; and positive regulation of Rac protein signal transduction. Predicted to be located in several cellular components, including axonal growth cone; cytoplasmic microtubule; and lamellipodium. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 875.5), CNS E14 (RPKM 291.0) and 24 other tissues See more
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    Genomic context

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    Location:
    17 A1; 17 4.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6869178..6877078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6601779..6607891)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2808 Neighboring gene predicted gene, 29721 Neighboring gene predicted gene, 53224 Neighboring gene STARR-positive B cell enhancer mm9_chr17:6657759-6658060 Neighboring gene STARR-positive B cell enhancers mm9_chr17:6806288-6806589 and mm9_chr17:6654863-6655163 Neighboring gene transmembrane protein 181C, pseudogene Neighboring gene STARR-positive B cell enhancers mm9_chr17:6600655-6600955 and mm9_chr17:6860503-6860804 Neighboring gene dynein light chain Tctex-type 1F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader E, et al. Cell, 1989 Sep 8. PMID 2570638
    2. Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. He S, et al. Nat Commun, 2023 Mar 27. PMID 36973253, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular transport of viral protein in host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain Tctex-type 1C
    Names
    Activator of G-protein signaling 2
    Dynein light chain Tctex-type 1
    T-complex testis-specific protein 1
    dynein light chain Tctex-type 1D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166630.1 → NP_001160102.1  dynein light chain Tctex-type 1C isoform 1

      See identical proteins and their annotated locations for NP_001160102.1

      Status: VALIDATED

      Source sequence(s)
      AK168478
      Consensus CDS
      CCDS57042.1
      UniProtKB/Swiss-Prot
      P51807, Q5M8S6
      UniProtKB/TrEMBL
      A1E5T5
      Related
      ENSMUSP00000090644.5, ENSMUST00000092966.5
      Conserved Domains (1) summary
      pfam03645
      Location:16 → 111
      Tctex-1; Tctex-1 family

    2. NM_001414431.1 → NP_001401360.1  dynein light chain Tctex-type 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167249

    3. NM_001414432.1 → NP_001401361.1  dynein light chain Tctex-type 1C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC167249

    4. NM_001414433.1 → NP_001401362.1  dynein light chain Tctex-type 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC167249

    5. NM_001414434.1 → NP_001401363.1  dynein light chain Tctex-type 1C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC167249

    6. NM_001414435.1 → NP_001401364.1  dynein light chain Tctex-type 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC167249

    7. NM_001414436.1 → NP_001401365.1  dynein light chain Tctex-type 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC167249

    8. NM_001414437.1 → NP_001401366.1  dynein light chain Tctex-type 1C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC167249

    RNA

    1. NR_182436.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167249

    2. NR_182437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC167249

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6869178..6877078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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