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    GLIP2 GDSL-motif lipase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841833, updated on 7-Sep-2023

    Summary

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    Gene symbol
    GLIP2
    Gene description
    GDSL-motif lipase 2
    Primary source
    Araport:AT1G53940
    Locus tag
    AT1G53940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GDSL-motif lipase 2; T18A20.17
    Summary
    Encodes a lipase, has in vitro lipase activity with p-nitrophenyl acetate and p-nitrophenyl butyrate, gene expression induced by hormones, negatively regulates auxin signaling, involved in disease resistance
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    Genomic context

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    See GLIP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (20143144..20144974)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene polyubiquitin-like protein Neighboring gene ubiquitin-40S ribosomal S27a-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis GDSL lipase 2 plays a role in pathogen defense via negative regulation of auxin signaling. Lee DS, et al. Biochem Biophys Res Commun, 2009 Feb 20. PMID 19146828
    2. Secretome analysis reveals an Arabidopsis lipase involved in defense against Alternaria brassicicola. Oh IS, et al. Plant Cell, 2005 Oct. PMID 16126835, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that GLIP2 plays a role in resistance to Erwinia carotovora via negative regulation of auxin signaling.
      Title: Arabidopsis GDSL lipase 2 plays a role in pathogen defense via negative regulation of auxin signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of auxin mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GDSL-motif lipase 2
    NP_001319218.1
    • GDSL-motif lipase 2 (GLIP2); FUNCTIONS IN: lipase activity, arylesterase activity, carboxylesterase activity; INVOLVED IN: response to jasmonic acid stimulus, response to ethylene stimulus, defense response to bacterium, response to salicylic acid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: seedling, stem, cotyledon, hypocotyl, root; CONTAINS InterPro DOMAIN/s: Lipase, GDSL, active site (InterPro:IPR008265), Lipase, GDSL (InterPro:IPR001087); BEST Arabidopsis thaliana protein match is: GDSL lipase 1 (TAIR:AT5G40990.1); Has 3238 Blast hits to 3145 proteins in 120 species: Archae - 0; Bacteria - 110; Metazoa - 0; Fungi - 27; Plants - 3095; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20143144..20144974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333621.1 → NP_001319218.1  GDSL-motif lipase 2 [Arabidopsis thaliana]

      Status: REVIEWED

    2. NM_104272.2 → NP_175797.2  GDSL-motif lipase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HTF4, Q9SYF0
      UniProtKB/TrEMBL
      A0A5S9WRM7
      Conserved Domains (1) summary
      cd01837
      Location:39 → 360
      SGNH_plant_lipase_like; a plant specific subfamily of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYF0.1

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