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    Cyt-b5-r Cytochrome b5-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35008, updated on 10-May-2024

    Summary

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    Official Symbol
    Cyt-b5-rprovided by FlyBase
    Official Full Name
    Cytochrome b5-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000406
    Locus tag
    Dmel_CG13279
    See related
    AllianceGenome:FB:FBgn0000406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13279; Cyt-b; Cyt-b5; Cytb; Cytb5; Cytb5r; Dmel\CG13279; TU-36B; TU36B
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including circulatory system; embryonic/larval fat body; extended germ band embryo; muscle cell; and yolk nucleus. Orthologous to human FADS1 (fatty acid desaturase 1); FADS2 (fatty acid desaturase 2); and FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cyt-b5-r in Genome Data Viewer
    Location:
    36B1-36B1; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16788774..16790721, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16788774..16790721, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene yellow-b Neighboring gene pickpocket 17 Neighboring gene Myosin heavy chain Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 37 member C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and translocation of Drosophila nuclear encoded cytochrome b(5) proteins to mitochondria. Kula ME, et al. Insect Biochem Mol Biol, 2000 Oct. PMID 10899459
    2. Structure and expression of a muscle specific gene which is adjacent to the Drosophila myosin heavy-chain gene and can encode a cytochrome b related protein. Levin RJ, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2549511, Free PMC Article
    3. Biochemical membrane lipidomics during Drosophila development. Guan XL, et al. Dev Cell, 2013 Jan 14. PMID 23260625
    4. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Lemos B, et al. Science, 2008 Jan 4. PMID 18174442
    5. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. Zhao X, et al. J Clin Invest, 2012 Jul. PMID 22684109, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome b5-related
    Names
    CG13279-PA
    CG13279-PB
    Cyt-b5-r-PA
    Cyt-b5-r-PB
    NP_001260514.1
    NP_477154.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16788774..16790721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273585.1 → NP_001260514.1  cytochrome b5-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19967, Q9VJI2
      UniProtKB/TrEMBL
      M9PD26
      Conserved Domains (3) summary
      pfam00173
      Location:26 → 98
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00487
      Location:161 → 408
      FA_desaturase; Fatty acid desaturase
      cl00615
      Location:328 → 385
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...

    2. NM_057806.5 → NP_477154.1  cytochrome b5-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19967, Q9VJI2
      UniProtKB/TrEMBL
      M9PD26
      Related
      FBpp0080486
      Conserved Domains (3) summary
      pfam00173
      Location:26 → 98
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00487
      Location:161 → 408
      FA_desaturase; Fatty acid desaturase
      cl00615
      Location:328 → 385
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD26 M9PD26
    P19967.2 P19967

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