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    ATHB-15 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841645, updated on 7-Sep-2023

    Summary

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    Gene symbol
    ATHB-15
    Gene description
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    Primary source
    Araport:AT1G52150
    Locus tag
    AT1G52150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHB15; CNA; CORONA; F5F19.21; F5F19_21; ICU4; INCURVATA 4
    Summary
    Member of the class III HD-ZIP protein family. Contains homeodomain and leucine zipper domain. Critical for vascular development and negatively regulates vascular cell differentiation.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (19409688..19414764, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Mannose-binding lectin superfamily protein Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene uncharacterized protein Neighboring gene tRNAse Z3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis. Du Q, et al. Plant J, 2015 Aug. PMID 26043238
    2. Arabidopsis shoot organogenesis is enhanced by an amino acid change in the ATHB15 transcription factor. Duclercq J, et al. Plant Biol (Stuttg), 2011 Mar. PMID 21309978
    3. Alteration of the shoot radial pattern in Arabidopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4. Ochando I, et al. Int J Dev Biol, 2008. PMID 18956325
    4. Overexpression of miR165 affects apical meristem formation, organ polarity establishment and vascular development in Arabidopsis. Zhou GK, et al. Plant Cell Physiol, 2007 Mar. PMID 17237362
    5. microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems. Kim J, et al. Plant J, 2005 Apr. PMID 15773855, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms.
      Title: CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules.
    2. Transgenic over-expression of a mutant form of AtHB15 that is resistant to miR165-mediated cleavage reversed the stp-2d mutant phenotype to wild-type, indicating that AtHB15 represses secondary wall development in pith.
      Title: Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis.
    3. stem cell specification pathway is normally repressed by the activity of the HD-zip III transcription factors PHABULOSA (PHB), PHAVOLUTA (PHV) and CORONA (CNA).
      Title: A WUSCHEL-Independent Stem Cell Specification Pathway Is Repressed by PHB, PHV and CNA in Arabidopsis.
    4. An amino acid substitution in the class III HD-ZIP transcription factor ATHB15 enhanced shoot organogenesis.
      Title: Arabidopsis shoot organogenesis is enhanced by an amino acid change in the ATHB15 transcription factor.
    5. Alteration of the shoot radial pattern in Arabidiopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4 is reported.
      Title: Alteration of the shoot radial pattern in Arabidopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4.
    6. Regulation of ATHB15 in a mutatnt A. thaliana that affects vascular cell differentiation and inflorescence elongation.
      Title: microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems.
    7. Class III HD-Zip AND KANADI genes required for root development [ATHB15]
      Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084233.2
    NM_104096.3
    NM_179464.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of bilateral symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within integument development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    NP_001077702.1
    • ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3126 Blast hits to 3055 proteins in 249 species: Archae - 0; Bacteria - 0; Metazoa - 767; Fungi - 91; Plants - 2233; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).
    NP_175627.1
    • ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3146 Blast hits to 3075 proteins in 258 species: Archae - 0; Bacteria - 18; Metazoa - 766; Fungi - 90; Plants - 2237; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).
    NP_849795.1
    • ATHB-15; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox gene 8 (TAIR:AT4G32880.1); Has 3139 Blast hits to 3068 proteins in 257 species: Archae - 0; Bacteria - 18; Metazoa - 766; Fungi - 90; Plants - 2230; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19409688..19414764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104096.3 → NP_175627.1  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5EE12, Q9FWZ0, Q9ZU11
      UniProtKB/TrEMBL
      A0A5S9WR09, A0A654EHN9
      Conserved Domains (4) summary
      cd08875
      Location:155 → 371
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      cd14686
      Location:69 → 108
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam00046
      Location:17 → 75
      Homeobox; Homeobox domain
      pfam08670
      Location:692 → 835
      MEKHLA; MEKHLA domain

    2. NM_001084233.2 → NP_001077702.1  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WR09, F4IBA6
      Conserved Domains (4) summary
      cd08875
      Location:155 → 371
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      cd14686
      Location:69 → 108
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam00046
      Location:17 → 74
      Homeobox; Homeobox domain
      pfam08670
      Location:692 → 788
      MEKHLA; MEKHLA domain

    3. NM_179464.1 → NP_849795.1  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WR09, B3H4G8
      Conserved Domains (4) summary
      cd08875
      Location:155 → 371
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      cd14686
      Location:69 → 108
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam00046
      Location:17 → 74
      Homeobox; Homeobox domain
      pfam08670
      Location:693 → 832
      MEKHLA; MEKHLA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZU11.1

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